李琳

[摘要] 目的 分析伊曲康唑联合丹翘酊治疗马拉色菌毛囊炎疗效及皮疹评分情况。 方法 方便选择2018年9月—2019年9月该院收治马拉色菌毛囊炎患者90例，按随机数表分为两组，对照组45例使用伊曲康唑联合联苯苄唑乳膏治疗，研究组45例采用伊曲康唑联合丹翘酊治疗，对两组临床疗效及皮疹评分进行比较。 结果 对照组临床总有效73.33%明显比研究组91.11%低（χ2=4.865， P<0.05）;研究组皮疹评分第2周（7.83±0.81）分、第4周（6.55±0.91）分、第8周（4.34±0.47）分明显比对照组低，差异有统计学意义（t=4.525、5.653、14.108，P<0.05）;研究组生活质量（89.29±10.52）分明显比对照组（72.72±12.83）分高，差异有统计学意义（t=6.700， P<0.05）。 结论 对马拉色菌毛囊炎患者使用伊曲康唑联合丹翘酊治疗，可改善患者皮疹情况，提高其生活质量，还能提升治疗效果。

[关键词] 伊曲康唑;丹翘酊;马拉色菌性毛囊炎;临床疗效;皮疹评分

[中图分类号] R8          [文献标识码] A          [文章编号] 1674-0742（2020）08（c）-0093-03

[Abstract] Objective To analyze the effect of itraconazole combined with Danqiao tincture in the treatment of Malassezia folliculitis and the rash score. Methods From September 2018 to September 2019， 90 patients with Lassezia folliculitis were convenient selected and divided into two groups according to the random number table. The control group was treated with itraconazole combined with bifonazole cream in 45 cases; 45 cases in the study group were treated with itraconazole combined with Danqiao tincture， and the clinical efficacy and rash scores of the two groups were compared. Results The total clinical effective 73.33% of the control group was significantly lower than the 91.11% of the study group （χ2=4.865， P<0.05）; the rash score of the study group for the second week was （7.83±0.81）points， the fourth week was （6.55±0.91）points， and the eighth week （4.34±0.47）points， which were significantly lower than that of the control group， and the differences were statistically significant （t=4.525，5.653， 14.108， P<0.05）; the quality of life of the study group （89.29±10.52） points was significantly lower than that of the control group （72.72±12.83）points， and the difference was statistically significant （t=6.700， P<0.05）. Conclusion The treatment of malassezia folliculitis patients with itraconazole combined with Danqiao tincture can improve the patient's rash， improve their quality of life， and improve the treatment effect.

[Key words] Itraconazole; Danqiao tincture; Malassezia folliculitis; Clinical efficacy; Rash score

馬拉色菌毛囊炎在临床皮肤科是一种较为常见的真菌性皮肤疾病，具有较高发病率及复发率，主要以16～40岁年龄段为多发群体，男性患病率高于女性[1]。马拉色菌毛囊炎主要是由马拉色菌感染所引起，一旦患上该疾病，患者可出现呈半球状的红色丘疹，颈肩是红色丘疹最为常发部位，而在胸背以及腰腹部位也可出现红晕现象，该红晕多为对称分布、数量不一、分布密集，通常情况下不会融合成片，若不及时进行有效干预，不仅会影响患者日常生活，严重时甚至会降低其生活质量[2-3]。目前，临床多给予抗真菌药物与外用洗液联合治疗该疾病，虽具有一定治疗效果，但由于该治疗方法治疗周期相对较长，病情易复发，其远期疗效不理想[4]。为提高患者疗效，该研究对2018年9月—2019年9月该院收治90例马拉色菌毛囊炎患者采取的不同治疗方案，分析伊曲康唑联合丹翘酊治疗马拉色菌毛囊炎疗效，现报道如下。

1  资料与方法