陈亚江

[摘要] 目的 讨论在糖尿病性视网膜病变患者的临床治疗过程中运用眼底激光、雷珠单抗联合疗法进行治疗的临床诊治效果。方法 筛选出2018年7月—2019年5月于该院进行诊治处理的糖尿病性视网膜病变患者120例，应用数字随机表对患者进行分组，即参照组与观察组。参照组运用眼底激光疗法，观察组运用眼底激光、雷珠单抗联合疗法。记录、对比两组的临床诊治结局。结果 接受治疗后，较之参照组，观察组的临床诊治（95.00%）有效性明显提升（P<0.05），观察组的渗出吸收时间、视网膜水肿症状改善时间、眼底出血吸收时间均呈现明显的缩减趋势（P<0.05），且观察组的黄斑区视网膜厚度呈现明显的提升趋势（P<0.05）;观察组的不良反应发生率（6.67%）明显缩减18.33%（P<0.05）。结论 在糖尿病性视网膜病变患者的临床治疗过程中运用眼底激光、雷珠单抗联合疗法进行治疗，诊治结局甚佳，能够有效缓解患者的临床症状，同时有助于加快患者视力水平的恢复进程，临床应用价值十分理想。

[关键词] 眼底激光;雷珠单抗;糖尿病性视网膜病变;临床疗效

[中图分类号] R77          [文献标识码] A          [文章编号] 1672-4062（2020）06（a）-0185-03

[Abstract] Objective To discuss the clinical diagnosis and treatment effect of combined treatment of fundus laser and ranibizumab in the clinical treatment of patients with diabetic retinopathy. Methods A total of 120 diabetic retinopathy patients who were diagnosed and treated in the hospital from July 2018 to May 2019 were selected， and the patients were divided into two groups using a digital random table， namely the reference group and the observation group. The reference group used fundus laser therapy， and the observation group used fundus laser and ranibizumab combination therapy. Record and compare the clinical diagnosis and treatment outcomes of the two groups. Results After receiving the treatment， the clinical diagnosis and treatment effectiveness（95.00%） of the observation group was significantly improved （P<0.05） compared with the reference group. The exudation and absorption time of the observation group， the improvement time of the symptoms of retinal edema， and the absorption time of fundus hemorrhage all showed obvious reduction trend （P<0.05）， and the retinal thickness of the macular area in the observation group showed a clear upward trend （P<0.05）; the incidence of adverse reactions in the observation group（6.67%） was significantly reduced by 18.33% （P<0.05）. Conclusion The use of fundus laser and ranibizumab combination therapy in the clinical treatment of patients with diabetic retinopathy has a very good diagnosis and treatment outcome， which can effectively relieve the clinical symptoms of patients and at the same time help to speed up the recovery process of patients' visual acuity ， The clinical application value is very ideal.

[Key words] Fundus laser; Ranibizumab; Diabetic retinopathy; Clinical efficacy

糖尿病是一种临床上较为常见的慢性疾病，多见于中老年群体。有研究指出，糖尿病的发生及发展与患者的机体代谢能力具有紧密的关联性。与此同时，随着年龄的不断增长，患者的神经功能将逐渐衰退，从而极易引发糖尿病性视网膜病变等并发症，致使患者的视觉功能受损、视力模糊、颜色分辨能力下降及视网膜存在明显的浮动斑点。调查显示，我国糖尿病患者中50%以上的患者均存在不同程度的糖尿病性视网膜病变，而在失明的年轻糖尿病患者中，超過90%是由糖尿病性视网膜病变所致。糖尿病性视网膜病变是一种临床上较为常见的糖尿病微血管并发症，同时也是一种对人体健康具有严重危害性的临床病症[1]。雷珠单抗是一种抑制剂，对血管内皮生长因子的释放进程具有明显的抑制作用，同时能够有效防治血管渗漏并阻断血管的新生路径，进而实现治疗糖尿病性视网膜病变的目的[2-3]。……