谭艳梅　熊亚平

【摘要】 目的：探讨多囊卵巢综合征不孕症采用二甲双胍联合炔雌醇环丙孕酮治疗的效果。方法：选取2014年10月-2018年5月筆者所在医院收治的88例多囊卵巢综合征不孕症患者，采用随机奇偶数分配的方式将其分为对照组及观察组，每组44例，对照组者采用炔雌醇环丙孕酮治疗，观察组联合二甲双胍治疗，对比两组治疗前后激素水平、治疗效果及不良反应发生情况。结果：治疗前两组激素水平比较差异无统计学意义（P>0.05），治疗后两组FSH、T及LH水平均低于治疗前，E2水平均高于治疗前，且观察组激素水平均优于对照组，差异均有统计学意义（P<0.05）;观察组治疗总有效率为97.73%，高于对照组的78.55%，差异有统计学意义（P<0.05）;观察组不良反应发生率为6.82%，对照组为4.55%，差异无统计学意义（P>0.05）。结论：针对多囊卵巢综合征不孕症患者，联合采用二甲双胍及炔雌醇环丙孕酮治疗激素水平改善显著，未见不良反应增多的情况，说明联合用药安全放心，临床使用价值更高。

【关键词】 多囊卵巢综合征 不孕症 二甲双胍 炔雌醇环丙孕酮 激素水平 治疗效果 不良反应

doi：10.14033/j.cnki.cfmr.2020.16.053 文献标识码 B 文章编号 1674-6805（2020）16-0-03

Effect of Metformin Combined with Ethylestradiol Cycloprogesterone in Treatment of Infertility with Polycystic Ovary Syndrome/TAN Yanmei， XIONG Yaping. //Chinese and Foreign Medical Research， 2020， 18（16）： -132

[Abstract] Objective： To investigate the effect of Metformin combined with Ethylestradiol Cyclopropanone in treatment of polycystic ovary syndrome （PCOS） infertile patients. Method： From October 2014 to May 2018， 88 infertile patients with polycystic ovarian syndrome were selected， and were randomly divided into the control group （n=44） and the observation group （n=44）. The control group was treated with Ethylestradiol Cycloprogesterone， and the observation group was combined with Metformin. The hormone levels， treatment effects and adverse reactions were compared between the two groups before and after treatment. Result： There was no statistically significant difference in hormone levels between the two groups before treatment （P>0.05）. After treatment， the FSH， T and LH levels in the two groups were lower than those before treatment， the E2 levels were higher than those before treatment， and the hormone levels in the observation group were better than those in the control group， the differences were statistically significant （P<0.05）. The total effective rate of the observation group was 97.73%， higher than 78.55% in the control group， the difference was statistically significant （P<0.05）. The incidence of adverse reactions was 6.82% in the observation group and 4.55% in the control group， there was no statistically significant difference （P>0.05）. Conclusion： For infertility patients with polycystic ovary syndrome， the combination of Metformin and Ethinylestradiol Cycloprogesterone showed significant improvement in hormone levels and no increase in adverse reactions， indicating that the combination was safe and of higher clinical value.

[Key words] Polycystic ovary syndrome Infertility Metformin Ethylestradiol Cycloproterone Hormone level Therapeutic effect Adverse reactions

First-authors address： Xianfeng County Peoples Hospital， Xianfeng 445600， China

多囊卵巢綜合征是妇科常见病，其最严重后果是导致不孕症。患者常有月经失调、多毛及肥胖，甚至闭经，且患者双侧卵巢增大、雄激素分泌水平过高及出现胰岛素抵抗，临床研究得知，疾病的发生与遗传、营养及内分泌失调有关，育龄女性发病率高达15%以上，使得疾病在临床得以关注[1]。口服避孕药是其常见治疗方式，其中炔雌醇环丙孕酮使用频率最高，但其作为临床一线用药存在一定争议，部分学者认为该种药物可能导致患者代谢紊乱，引发严重心血管疾病风险[2]。为提……