陈福萍

【摘要】 目的：探討癫痫患者血清同型半胱氨酸（Hcy）、血浆D-二聚体（D-D）及血浆C反应蛋白（CRP）的表达水平，并分析其与用药种类的相关性。方法：回顾性分析2017年6月-2019年12月笔者所在医院收治的75例癫痫患者临床资料，根据药物治疗控制情况，将难治性癫痫患者设为难治组（31例），将经抗癫痫药物控制良好者设为良好组（44例），另收集同期笔者所在医院接收的50例健康体检者设为对照组。检测所有受检者血清Hcy及血浆D-D、CRP水平，探讨其在癫痫患者中表达水平，并分析其与用药种类的关系。结果：难治组、良好组血清Hcy、血浆D-D、CRP水平均高于对照组，且难治组均高于良好组，差异有统计学意义（P<0.05）。不同用药种类患者D-D、CRP水平比较，差异均无统计学意义（P>0.05）。3种、2种用药种类患者Hcy水平高于1种用药种类患者，且3种用药种类患者高于2种用药种类患者，差异有统计学意义（P<0.05）。经Logistic回归分析显示，血清Hcy水平升高是癫痫患者用药种类增加的影响因素（P<0.05）。结论：血清Hcy、血浆D-D、CRP在癫痫患者中表达水平较高，高血清Hcy与服用多种抗癫痫药物种类具有密切关系，临床需重点关注。

【关键词】 癫痫 同型半胱氨酸 D-二聚体 C反应蛋白 用药种类 相关性

doi：10.14033/j.cnki.cfmr.2020.19.029 文献标识码 B 文章编号 1674-6805（2020）19-00-03

Expression Levels of Serum Hcy， Plasma D-D and CRP in Epileptic Patients and Their Correlation with Medication Types/CHEN Fuping. //Chinese and Foreign Medical Research， 2020， 18（19）： -75

[Abstract] Objective： To investigate the expression levels of serum homocysteine （Hcy）， plasma D-dimer （D-D） and plasma C-reactive protein （CRP） in epileptic patients， and to analyze their correlation with medication types. Method： The clinical data of 75 epileptic patients admitted in our hospital from June 2017 to December 2019 were retrospectively analyzed. According to the situation of medication therapy control， the refractory epileptic patients were set as the refractory group （31 cases）， and the patients with good antiepileptic medication control were set as the good group （44 cases）， and 50 healthy physical examinees received in our hospital during the same period were collected and set as the control group. The serum Hcy and plasma D-D and CRP levels of all the subjects were measured to explore their expression levels in epileptic patients， and their relationship with the types of medication was analyzed. Result： The serum Hcy， plasma D-D and CRP levels of the refractory group and the good group were all higher than those of the control group， and the refractory group was higher than the good group， and the differences were statistically significant （P<0.05）. There were no significant differences in D-D and CRP levels among patients with different medication types （P>0.05）. The Hcy level of patients with the 3 and 2 medication types was higher than that of patients with the 1 medication type， and patients with 3 medication types was higher than patients with 2 medication types， and the difference was statistically significant （P<0.05）. Logistic regression analysis showed that the increased serum Hcy level was an influential factor in the increase of medication types in epileptic patients （P<0.05）. Conclusion： The expression levels of serum Hcy， plasma D-D and CRP are high in epileptic patients， and high serum Hcy is closely related to the use of various types of antiepileptic medication， which should be paid attention to clinically.

[Key words] Epileptic Homocysteine D-dimer C-reactive protein Medication type Correlation

First-authors address： Wuwei Traditional Chinese Medicine Hospital， Wuwei 733000， China

癫痫是神经内科常见疾病之一，该病主要治疗方式为药物治疗，近年来虽然多种新型抗癫痫药物不断应用，但经治疗后，仍有部分患者病情得不到有效控制，为难治性癫痫，故探索控制癫痫有效办法成为临床研究重点[1]。研究表示，同型半胱氨酸（Hcy）是反应癫痫疾病有效指标之一，在患者体内具有较高水平;血浆D-二聚体（D-D）及血浆C反应蛋白（CRP）与脑卒中及脑损伤等具有密切关系[2]。但目前临床对三种指标在癫痫患者中的表达并未明确，且与用药种类关系的研究并不多见，基于此，本研究旨在探讨这三项指标在癫痫患者中的表达水平，以及与患者用药种类的关系，具体报道如下。……