李少雄 王维建

摘要目的：探究气道正压通气联合信必可都保治疗阻塞性睡眠呼吸暂停合并慢阻肺的临床疗效。方法：选取2018年10月至2019年10月綦江区人民医院收治的阻塞性睡眠呼吸暂停合并慢阻肺患者90例作为研究对象，随机分为观察组和对照组，每组45例。观察组采用气道正压通气联合信必可都保为患者治疗，对照组采用气道正压通气为患者治疗，治疗后对2组患者PSG指标和肺功能指标进行评估。结果：治疗后2组患者呼吸暂停时间、呼吸暂停指数及睡眠时SaO2指标均显著改善，但观察组患者改善幅度更为显著，数据经检验有统计学意义（P<005）;治疗后2组患者FEV1和6MWT水平均有提高，但观察组患者提高幅度更加显著，数据经检验具有统计学意义（P<005）。讨论：将气道正压通气联合信必可都保应用于阻塞性睡眠呼吸暂停合并慢阻肺的临床治疗当中，可有效提高患者睡眠质量，并可改善肺功能，效果显著，值得推广。

关键词持续气道正压通气;信必可都保;阻塞性睡眠呼吸暂停;慢性阻塞性肺疾病;临床效果

Clinical Effect of Positive Airway Pressure Ventilation Combined with Xinbibecodoubao on Obstructive Sleep Apnea Combined with Chronic Obstructive Pulmonary Disease

LI Shaoxiong，WANG Weijian

（Respiratory department of Qijiang District People′s Hospital，Chongqing 401420，China）

AbstractObjective：To investigate the clinical efficacy of continuous positive airway pressure combined with Symbicort tu rbuhaler in the treatment of obstructive sleep apnea hypopnea syndrome with chronic obstructive pulmonary diseaseMethods：A total of 90 patients with dual sleep apnea and chronic obstructive pulmonary disease admitted to our hospital from October 2018 to October 2019 were randomly divided into two groupsThe study group used continuous positive airway pressure combined with Symbicort tu rbicort was treated for patients，and instead of continuous positive airway pressure for patients，the PSG index and lung function index of the implanted patients were evaluated after treatmentResults：The apnea time，apnea index and sleep time SaO2 of the hospitalized patients were significantly improved after treatment，but the improvement of the study group was more significantThe data were statistically significant（P<005）The levels of FEV1 and 6MWT were elevated，but the increase was more significant in the study group，and the data were statistically significant（P<005）Conclusion：In the clinical treatment of obstructive sleep apnea hypopnea syndrome combined with chronic obstructive pulmonary disease combined with continuous positive airway pressure and Symbicort tu rbuhaler，it can effectively improve the patient′s sleep quality and improve lung function，and the effect is significant and worth promoting.

KeywordsContinuous positive airway pressure;Symbicort tu rbuhaler;Obstructive sleep apnea hypopnea syndrome;Chronic obstructive pulmonary disease;Clinical effect

中圖分类号：R3644;R33863文献标识码：Adoi：10.3969/j.issn.2095-7130.2020.06.070

阻塞性睡眠呼吸暂停是一种以打鼾、白天困倦、嗜睡等为主要临床表现的睡眠呼吸疾病[1]，反复发生睡眠呼吸暂停可导致患者并发高碳酸血症和多种心血管疾病，严重时可导致猝死[2]。本次研究报道如下。

1资料与方法

11一般资料选取2018年10月至2019年10月綦江区人民医院收治的阻塞性睡眠呼吸暂停合并慢阻肺患者90例作为研究对象，随机分为观察组和对照组，每组45例。患者均表现出打鼾、白天困倦、嗜睡、夜间惊醒等症状，经多导睡眠监测（PSG）诊断和影像学技术检查，患者均被确诊。对照组中男29例，女16例，年龄43～76岁，平均年龄（630±89）岁，病程1～9年，平均病程（40±14）年;观察组中男27例，女18例，年龄40～76岁，平均年龄（625±87）岁，病程1～7年，平均病程（38±13）年。……