降钙素原、D-二聚体、C反应蛋白、血沉、血常规在创伤骨科患者围手术期治疗中的临床意义
2020-08-09王俊杰娄朝晖
王俊杰 娄朝晖

[摘要] 目的 降钙素原(PCT)、D-二聚体(D-D)、C反应蛋白(CRP)、血沉、血常规在创伤骨科患者围手术期治疗中的临床意义。 方法 方便选择2018年9月—2019年4月期间创伤骨科诊治的60例患者作为研究对象,分为两组,分为未感染组和感染组,比对两组病患PCT、D-D、CRP、血沉、血常规等指标,并分析在这些指标在临床治疗中的意义。 结果 未感染组术后2 d的血沉(36.34±5.36)mm/h、CRP(47.64±4.36)mg/L、D-二聚体(2.43±1.01)mg/L、PCT(2.36±1.32)ng/mL、白细胞(14.19±4.31)×109/L、中性粒细胞(71.32±8.34)%,感染组术后2 d的血沉(40.34±4.24)mm/h、CRP(75.46±5.42)mg/L、D-二聚体(3.76±1.36)mg/L、PCT(4.34±3.15)ng/mL、白细胞(16.34±3.21)×109/L、中性粒细胞(77.35±8.49)%,比对后得知两组患者术后2 d的血沉、CRP、D-D水平、PCT、白细胞和中性粒细胞均明显高于术前(P<0.05),且感染组患者术后2 d的水平均高于未感染组患者术后2 d的水平(P<0.05)。结论 血沉、CRP、D-D、PCT、血常规等检测指标各有优缺点,其中不乏特异性高、敏感性高的检查指标,应该根据疾病种类和情况选择适合的检查项目。
[关键词] 降钙素原;D-二聚体;C反应蛋白;血沉;创伤骨科
[Abstract] Objective The clinical significance of procalcitonin (PCT), D-dimer (D-D), C-reactive protein (CRP), erythrocyte sedimentation and blood routine in the perioperative treatment of traumatic orthopedics patients. Methods Sixty patients diagnosed and treated in trauma orthopaedics from September 2018 to April 2019 were convenient selected as the research objects, divided into 2 groups, divided into uninfected group and infected group, and compared the PCT, DD, and CRP, blood sedimentation, blood routine and other indicators, between the two groups of patients, and analyze the significance of these indicators in clinical treatment. Results In the uninfected group, the erythrocyte sedimentation (36.34±5.36) mm/h, CRP (47.64±4.36) mg/L, D-dimer (2.43±1.01)mg/L, PCT (2.36±1.32) ng/mL, Leukocytes (14.19±4.31)×109/L, neutrophils (71.32±8.34)%, erythrocyte sedimentation (40.34±4.24) mm/h, CRP (75.46±5.42) mg/L, D- Dimer (3.76±1.36)mg/L, PCT (4.34±3.15) ng/mL, white blood cells (16.34±3.21)×109/L, and neutrophils (77.35±8.49)%. After the comparison, we learned that The levels of erythrocyte sedimentation, CRP, DD, PCT, leukocytes, and neutrophils were significantly higher than those before surgery (P<0.05), and the level of 2 d postoperatively in the infected group was higher than that in the uninfected group(P<0.05). Conclusion ESR, CRP, D-D, PCT, blood routine and other detection indicators have their own advantages and disadvantages. Among them, there are many specific and sensitive examination indicators, and appropriate examination items should be selected according to the type and condition of the disease.
[Key words] Procalcitonin; D-dimer; C-reactive protein; ESR; Traumatology
創伤骨科主要是治疗一些骨创类疾病,常见疾病有股骨骨折、髋部骨折、胫骨骨折、上肢骨折等[1],很多患者因为创伤比较大围术期容易发生感染、下肢深静脉血栓(DVT)等并发症,随着检验技术的发展出现了很多比较新的检查项目,比如降钙素原(PCT)、C反应蛋白(CRP)及血常规中的白细胞、中性粒细胞等指标可很好地反映患者的感染情况,而D-二聚体(D-D)和血沉等指标可很好地反映患者机体凝血和纤溶过程,是临床上评估患者机体凝血情况和纤溶情况的重要指标,为了探究PCT、D-D、CRP、血沉、血常规用于创伤骨科患者围手术期治疗中的临床意义,该次方便选取2018年9月—2019年4月期间创伤骨科诊治的60例患者作为研究对象进行研究,现报道如下。
1 资料与方法
1.1 一般资料
方便选择创伤骨科诊治的60例患者作为研究对象,分为两组,分为未感染组和感染组,纳入标准:①入组前所有患者均经过协商,且同意加入该研究,该次研究通过了伦理委员会的批准;②受伤时间不超过24 h;③患者无恶性肿瘤史;④患者无血栓性疾病史;⑤患者无凝血功能障碍性疾病史。……
