梁云飞 郭雪琴 陈健 许锦泉 李彩珍

【摘要】 目的：研究早期干预对首发精神分裂症的疗效及持续用药时间。方法：选取2018年5-10月

本院收治的60例首发精神分裂症患者作为研究对象，将患者随机分为早期干预组和普通治疗组，每组30例。比较两组干预前、干预2个月后阳性和阴性症状量表（PANSS）、临床疗效总评量表（CGI）、日常生活能力量表（ADL）评分，对比两组干预2个月后的疗效，比较两组服药依从性及出院后各时间点持续用药人数。结果：早期干预组干预2个后PANSS、CGI、ADL评分均低于普通治疗组（P<0.05）;早期干预组服药依从性高于普通治疗组，出院后3、9、12个月持续用药人数均较普通治疗组多，差异均有统计学意义（P<0.05）。结论：早期干预首发精神分裂症能提高临床疗效，提高患者服药依从性从而延长持续用药时间，有利于促进患者康复及预防复发。

【关键词】 早期干预 首发精神分裂症 疗效 持续用药时间

Effect of Early Intervention on First-episode Schizophrenia and Duration of Druguse/LIANG Yunfei， GUO Xueqin， CHEN Jian， XU Jinquan， LI Caizhen. //Medical Innovation of China， 2020， 17（13）： -134

[Abstract] Objective： To study the effect of early intervention on first-episode schizophrenia and duration of medication. Method： A total of 60 first-episode schizophrenics admitted to our hospital from May to October 2018 were selected as research subjects， the patients were randomly divided into the early intervention group and the general treatment group， 30 patients in each group. The scores of positive and negative symptom scale （PANSS）， general clinical efficacy rating scale （CGI） and daily living ability scale （ADL） before and after intervention were compared between two groups， and the efficacy of two groups after 2 months of intervention were compared. Result： The scores of PANSS， CGI， ADL in the early intervention group 2 months after interventions were lower than those of general treatment group （P<0.05）. The medication compliance of the early intervention group was higher than that of general treatment group， the number of patients with continuous medication 3， 9 and 12 months after discharge were higher than those of the general treatment group， with statistically significant differences （P<0.05）. Conclusion： Early intervention in the first-episode schizophrenia can improve the clinical efficacy， improve patients medication compliance and thus prolong the duration of medication， which is conducive to promoting the recovery of patients and preventing recurrence.

[Key words] Early intervention First-episode schizophrenia Efficacy Duration of medication

First-authors address： The Third Peoples Hospital of Zhanjiang City， Zhanjiang 524012， China

doi：10.3969/j.issn.1674-4985.2020.13.033

精神分裂癥是临床上最常见的严重精神疾病，可表现为症状各异的综合征，如情感、思想、行为等表现障碍及精神活动产生不协调等[1-2]。临床上针对精神分裂症的治疗也主要以药物为主，然而约1/3患者药物疗效欠佳，容易精神致残导致生活质量、社会功能等下降[3-5]。近20年来如何对精神分裂症患者实施早期干预引起人们的极大关注，早期识别和早期干预治疗可潜在地改善患者长期结局的效果，对于缓解症状与减少复发十分重要[6-7]。为此，选取本院60例首发精神分裂症患者作为研究对象，研究早期干预对首发精神分裂症的疗效及持续用药时间的影响，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年5-10月本院收治的首发精神分裂症患者60例作为研究对象。纳入标准：诊断符合中国精神障碍分类与诊断标准第3版（CCMD-Ⅲ）中精神分裂症的诊断标准。……