王翠萍　王倩倩

【摘 要】目的：早期肾功能损害应用尿微量蛋白联合血清胱抑素检验的价值分析。方法：选取2017年10月至2018年10月本院收治的疑似早期肾功能损害的120例患者临床资料，伴糖尿病65例设为研究A组，伴高血压55例设为研究B组，同期60例健康体检者设为对照组，检测并分析三组尿微量蛋白、血清胱抑素C检验结果。结果：研究A组、研究B组血清胱抑素C、尿微量白蛋白比对照组高，且研究A组比研究B组高，比较差异具有统计学意义（P<0.05）;研究A组、研究B组联合检验阳性率，均比单用血清胱抑素C、尿微量白蛋白高，比較差异具有统计学意义（P<0.05）;血清胱抑素C联合尿微量白蛋白检验准确度为98.33%（118/120），比单用血清胱抑素C 83.33%（100/120）、尿微量白蛋白85.00%（102/120）均高，比较差异具有统计学意义（P<0.05）。结论：早期肾功能损害疾病可应用尿微量蛋白联合血清胱抑素C检验，其尿微量蛋白、血清胱抑素C水平上升，且伴糖尿病相关指标比高血压高，可用于临床尽早诊断及有效治疗。

【关键词】尿微量蛋白;血清胱抑素C;早期;肾功能损害;检验;价值

The effect of combined detection of urine microprotein and serum cystatin C in the diagnosis of early renal dysfunction

Wang Cuiping，Wang Qianqian

The Seventh People's Hospital of Zibo City， Zibo， Shandong 255040

[Abstract] Objective：To analyze the value of urine microprotein combined with serum cystatin in early renal dysfunction. Methods： The clinical data of 120 patients with suspected early renal function impairment from October 2017 to October 2018 were selected. 65 patients with diabetes were enrolled in study group A， 55 patients with hypertension were enrolled in study group B， and 60 patients in the same period. The healthy physical examination was set as the control group， and the results of three groups of urine microprotein and serum cystatin C test were detected and analyzed. Results： Serum cystatin C and urinary albumin in group A and group B were higher than those in the control group， and the study group A was higher than the group B， and the difference was statistically significant （P<0.05）. The positive rate of combined test in group B was higher than that of serum cystatin C and urinary albumin， and the difference was statistically significant （P<0.05）. The accuracy of serum cystatin C combined with urine microalbumin was 98.33. %（118/120） was higher than serum cystatin C 83.33% （100/120） and urine microalbumin 85.00% （102/120）， and the difference was statistically significant （P<0.05）. Conclusion： Early renal function damage disease can be detected by urine microprotein combined with serum cystatin C. The levels of urinary microprotein and serum cystatin C are increased， and the diabetes-related index is higher than hypertension. It can be used for early diagnosis and effective treatment.

[Key words]Urinary microprotein; Serum cystatin C; Early; Renal dysfunction; Test; Value

高血压、糖尿病为临床常见慢性疾病，其病程比较长，且会随着疾病进展并发眼、心脏、肾等各系统不同程度的损害，影响患者正常生活质量[1]。其中早期肾功能损害患者，因进展缓慢，且症状不明确，常规肾功能检测不能进行有效诊断[2]。为进一步提升肾功能损害的早期诊断准确性，本研究主要对2017年10月至2018年10月诊治的疑似早期肾功能损害120例患者应用尿微量蛋白联合血清胱抑素C检验资料进行分析，报告如下。

1 资料与方法

1.1 一般资料

选取2017年10月至2018年10月诊治的疑似早期肾功能损害120例患者的临床资料，患者均签署相关知情同意书，症状、血常规等资料符合高血压、糖尿病伴早期肾功能损害相关诊断标准;纳入：无恶性肿瘤者，主动配合者，资料完整者。排除：精神心理病者，肝肾相关功能不完整者。伴糖尿病65例设为研究A组，其中男性39例，女性26例，年龄35～73岁，平均（56.56±7.67）岁，病程（7.63±2.06）年;伴高血压……