易云

【摘要】 目的：探討安宫黄体酮联合甲状腺素片对卵巢早衰患者的有效性及免疫功能的影响。方法：选择2017年12月-2018年12月卵巢早衰患者80例作为研究对象，按随机数字表法分为对照组（n=40）和观察组（n=40）。对照组给予激素替代疗法联合安宫黄体酮治疗，观察组在对照组基础上采用甲状腺素片治疗。治疗后对患者治疗效果进行评估，比较两组治疗前后激素水平及免疫功能指标。结果：观察组治疗后总有效率显著高于对照组（P<0.05）;两组治疗前激素水平比较，差异均无统计学意义（P>0.05）;观察组治疗后FSH、LH水平均显著低于对照组（P<0.05）;两组治疗前免疫功能指标比较，差异均无统计学意义（P>0.05）。观察组治疗后CD8+水平显著低于对照组，CD4+水平显著高于对照组（P<0.05）。结论：将安宫黄体酮联合甲状腺素片用于卵巢早衰患者中能提高患者免疫功能，增强治疗效果，值得推广应用。

【关键词】 安宫黄体酮 甲状腺素片 卵巢早衰 应用效果

doi：10.14033/j.cnki.cfmr.2019.30.026 文献标识码 B 文章编号 1674-6805（2019）30-00-03

[Abstract] Objective： To investigate the efficacy of Provera combined with Thyroxine Tablets in patients with premature ovarian failure and influence on immune function. Method： A total of 80 cases of patients with premature ovarian failure from December 2017 to December 2018 were selected as subjects. According to the random number table， the patients were divided into the control group （n=40） and the observation group （n=40）. The control group was given hormone replacement therapy combined with Provera， and the observation group was treated with Thyroxine Tablets on the basis of the control group. After treatment， the treatment effect of the patients was evaluated， and the hormone levels and the immune function indexes before and after treatment were compared between the two groups. Result： After treatment， total effective rate of the observation group was significantly higher than that of the control group （P<0.05）. Hormone levels before treatment were compared between the two groups， and the differences were not statistically significant （P>0.05）. After treatment， FSH and LH levels in the observation group were significantly lower than those of the control group （P<0.05）. The indexes of immune function before treatment were compared between the two groups， and the differences were not statistically significant （P>0.05）. After treatment， the CD8+ level in the observation group was significantly lower than that of the control group， and the CD4+ level was significantly higher than that of the control group （P<0.05）. Conclusion： Using Provera combined with Thyroxine Tablets in patients with premature ovarian failure can improve the patients immune function and enhance the therapeutic effect， which is worthy of promotion and application.

[Key words] Provera Thyroxine Tablets Premature ovarian failure Application effect

First-authors address： Xiangyang Hospital of Traditional Chinese Medicine， Xiangyang 441000， China

卵巢早衰为临床上较常见的女性内分泌紊乱疾病，是指卵巢功能衰竭而造成40岁前闭经的现象。卵巢早衰是一种多病因的综合征，大部分病例的病因尚不明确。目前，临床将卵巢早衰的发病原因主要分为遗传因素、免疫因素两个方面[1]。两个病因均可从某个方面减少卵巢内卵泡池的储备或引发卵泡功能失调而造成卵巢早衰。临床表现为潮热多汗、闭经、腰膝酸软、面部潮红、性欲低下等，严重影响患者的身心健康和生活质量，甚至会影响生育能力[2]。卵巢早衰的治疗方法有雌孕激素替代治疗、促排卵治疗、DHEA治疗、赠卵胚胎移植术等，虽然都具有一定的效果，但有的效果并不显著，可伴有其他并发症的发生。近年来，女性卵巢早衰的发病率有逐年升高的趋势[3]。……