徐青青

【摘要】 目的：探討癫痫部分性认知功能障碍患者采取奥卡西平治疗对患者认知功能及血清同型半胱氨酸（HCY）、C反应蛋白（CRP）的影响。方法：选取癫痫部分性认知功能障碍患者70例，按照随机数字表法分为对照组和观察组，各35例。对照组治疗药物为卡马西平，观察组治疗药物为奥卡西平，比较两组认知功能改善情况，治疗前后HCY、CRP水平变化。结果：观察组治疗总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前两组FIQ评分比较差异无统计学意义（P>0.05）;治疗后观察组FIQ评分均高于治疗前及对照组治疗后，差异均有统计学意义（P<0.05）;对照组治疗前后FIQ评分比较差异无统计学意义（P>0.05）。治疗前两组HCY、CRP水平比较差异无统计学意义（P>0.05）;治疗后两组HCY、CRP水平均升高，但观察组HCY、CRP水平均低于对照组，差异均有统计学意义（P<0.05）。治疗前两组生活质量评分比较差异无统计学意义（P>0.05）;治疗后观察组生活质量评分高于对照组，差异有统计学意义（P<0.05）。结论：癫痫部分性认知功能障碍患者采取奥卡西平治疗可改善患者认知功能，同时对HCY和CRP产生的影响较小，有利于患者生活质量水平的提高。

【关键词】 癫痫 认知功能障碍 奥卡西平 卡马西平 C反应蛋白 同型半胱氨酸

doi：10.14033/j.cnki.cfmr.2019.30.019 文献标识码 B 文章编号 1674-6805（2019）30-00-03

[Abstract] Objective： To investigate the effect of Oxcarbazepine on cognitive function and serum homocysteine （HCY）， C reactive protein （CRP） in partial cognitive impairment patients. Method： A total of 70 partial cognitive impairment patients who were randomly divided into the control group and the observation group， 35 cases in each group. The control group was treated with Carbamazepine， the observation group was treated with Oxcarbazepine， the improvement of cognitive function and the level of HCY， CRP before and after treatment of the two groups were compared. Result： The total effective rate of the observation group was higher than that of the control group， the difference was statistically significant （P<0.05）. There was no significant difference between the two groups of FIQ scores before treatment （P>0.05）， after the treatment， the FIQ scores of the control group were higher than that of the control group （P<0.05）， and there was no significant difference in the FIQ scores before and after the treatment （P>0.05）. There was no significant difference in the level of HCY， CRP between the two groups before treatment， but the level of HCY， CRP in the observation group were lower than those in the control group after treatment， but the level of HCY， CRP in the observation group were significantly lower than those in the control group （P<0.05）. There was no significant difference in quality of life score between the two groups before treatment （P>0.05）， but the quality of life score in the observation group was higher than that in the control group after treatment （P<0.05）. Conclusion： Oxcarbazepine in the treatment of partial cognitive impairment patients can improve the cognitive function of patients， and it has little effect on HCY and CRP， which is beneficial to improve the life quality of life patients.

[Key words] Epilepsia Cognitive impairment Oxcarbazepine Carbamazepine C-reactive protein Homocysteine

First-authors address： Maojian District Peoples Hospital of Shiyan City， Shiyan 442000， China

癫痫具备较高的发病率，其属于神经系统疾病。癫痫具备较为复杂的发病机制，目前临床研究中对于其具体发病机制尚无统一定论[1]。有资料报道称，癫痫发作后容易导致机体出现认知功能障碍，其会导致患者的生活质量严重降低[2]。并且有研究报道认为，甲状腺功能减退症的发生可能受到癫痫的影响[3]。奥卡西平属于新型抗癫痫治疗药物，其可使电压依赖性钠离子通道被有效阻断，虽然该药物属于卡马西平的衍生物，但其与卡马西平所具备的治疗效果却具有较大差异[4]。相较之下奥卡西平不容易产生对肝药酶的诱导。但……