王昭 钟远惠 陈胜林

[摘要]目的 探讨多感官刺激对阿尔茨海默病患者兴奋激越症状及生活质量的影响。方法 采用连续取样法选取2016年4月～2017年3月梅州市第三人民医院和广州市民政局精神病院收治的100例阿尔茨海默病患者作为研究对象，随机分为研究组和对照组，每组各50例。两组均接受常规药物治疗，在此基础上，研究组加用音乐疗法和触摸疗法等多重感官刺激治疗，比较两组治疗对改善阿尔茨海默病患者兴奋激越症状（BPRS）及提高生活质量的效果。结果 两组患者干预后的兴奋激越症状及生活质量评分均明显改善，研究组简易精神情况评估量表（MMSE）和简明精神病量表（BPRS）评分显著优于对照组，差异有统计学意义（P<0.05）；研究组阿尔茨海默病生活质量量表（QOL-AD）评分高于对照组，差异有统计学意义（P<0.05）。结论 多重感官刺激疗法不但能使患者症状得到更好的提升，极大改善患者的生活状况，有效降低患者的死亡率，保证患者的生活质量和生命，还可以直接减轻患者的家庭经济负担和照料者的精神压力。

[关键词]多重感官刺激；阿尔茨海默病；兴奋激越症状；生活质量

[中图分类号] R543 [文献标识码] A [文章编号] 1674-4721（2018）7（a）-0069-04

[Abstract]Objective To investigate the effects of multi-sensory stimulation on the symptoms of excitatory agitation and quality of life in the patients with Alzheimer′s disease.Methods A total of 100 patients with Alzheimer′s disease who were admitted to the Third People′s Hospital of Meizhou City and Psychiatric Hospital of Bureau of Civil Affairs of Guangzhou Municipality from April 2016 to March 2017 were selected by the continuous sampling method.The patients were randomly divided into study group and control group，with 50 cases in each group.Both groups were given conventional medical treatment.On this basis，the research group was further given multi-sensory stimulation such as music therapy and touch therapy.The effects of the two groups of treatment on improving symptoms of excitatory agitation （BPRS） and improving the quality of life in the patients with Alzheimer′s disease were compared.Results After the intervention，the excitatory agitation and quality of life scores were significantly improved in both groups.The MMSE and BPRS scores in the research group were significantly better than those in the control group，and the differences were statistically significant （P<0.05）.The Alzheimer′s Disease Quality of Life Scale （QOL-AD） score in the research group was higher than that in the control group，and the difference was statistically significant （P<0.05）.Conclusion Multi-sensory stimulation not only improves the symptoms of patients，but also greatly improves the patients′ living conditions，effectively reduces patients′ mortality rate and ensures their quality of life.It can also directly reduce the economic burden on the patient′s family and the mental stress of the caregiver.

[Key words]Multi-sensory stimulation；Alzheimer′s disease；Excitatory agitation；Quality of life

随着年龄的增长，很多老年人往往会出现一些不良的反应，如智力降低，记忆力、推理能力降低和行為、性格发生明显变化，患者通常会表现出反应缓慢、生活不能自理、行动能力障碍等一组症候群。在医学上称为慢性器质性疾病，通常称为阿尔茨海默病，是老年人一组常见的症状[1]。治疗阿尔茨海默病的药物研发已经成为医学界关注的重点问题。然而，因为阿尔茨海默病不属于同源性疾病的范围，导致疾病出现的主要原因不清楚，所以现如今还没有很好的治疗方式，并且现行的药物治疗效果都不理想。现如今阿尔茨海默病主要通过两类方式进行治疗： 一类是通过药物干预的方式进行治疗， 另一类通过非药物干预的方式进行治疗[2]。……