摘 要 目的：评价中药治疗半表半里证的疗效，总结其用药规律。方法：通过检索国内治疗半表半里证的临床文献，以纳入排除标准进行筛选，对纳入后的文献作出Meta分析，并总结其用药规律。结果：本研究共纳入2篇文章，均为低质量文献，Meta分析显示，中药治疗半表半里证试验组效果优于对照组（P<0.01）。治疗半表半里证的首选配伍为柴胡、黄芩、白术。结论：中药治疗半表半里证效果良好，同时基于Meta分析上，总结出其用药规律，但仍需临床实践中验证。

关键词 半表半里 Meta分析 用药规律

中图分类号：R243 文献标志码：C 文章编号：1006-1533（2018）19-0033-02

Meta-analysis of regularity of prescription in patients with semi-exterior-interior syndrome*

SHI Xiaoqian**

（Hui Medical College of Traditional Chinese Medicine， Ningxia Medical University， Yinchuan 750001， China）

ABSTRACT Objective： To investigate the effect of traditional Chinese medicine on patients with semi-exterior-interior syndrome. Methods： The clinical literatures on the treatment of semi-exterior-interior were selected according to the inclusion and exclusion criteria and were analyzed by meta， and the regularity of prescription was summarized. Results： This study was involved in a total of 2 papers though belonging to low quality. Meta-analysis showed that the effect of tradition Chinese medicine for the treatment of this syndrome was significantly better in the experimental group than the control group （P<0.01）. The preferred combination of prescription was radix bupleuri， scutellaria baicalensis and atractylodes. Conclusion： Traditional Chinese medicine for the treatment of semi-superficial and semi-internal syndrome has good efficacy. The regularity of medication is summarized based on meta-analysis， however， it will remain to be further verified in clinical practice.

KEy WORDS semi-exterior-interior syntrome； meta-analysis； regularity of prescription

“半表半里”是中醫学中一种特殊的理论，它是一种既不在表，又不在里，介乎于表里之间的病位。若邪气侵犯于此，则会产生“半表半里证”。半表半里证最常见的临床表现为往来寒热，又称“寒热往来”[1]。因邪气侵犯病位属于半表半里，此病位特殊，外连肌肤腠理，内连脏腑经络，人体正气在此与邪气抗争，影响腠理卫气通行、脏腑经络交通，且邪气一时难以祛除，正气不断与之抗衡，正胜则热，邪胜则寒，故产生往来寒热的表现[2]。

近年来，“半表半里”的研究逐年增加，但是对其用药规律的探寻仍是欠缺。中国学术文献网络出版总库等科技论文以“半表半里”、“往来寒热”主题学术论文达1 245篇，但其中关于其用药规律的文献1篇，由此可见，该领域是一块空白，待科研工作者继续完善。故笔者用循证医学Meta分析，它是对同一研究的多项研究结果一致性的综合评价方法，在治疗、预防预后等方面起着独特的作用，可解决独立研究不能解决的问题[3]，综合评价中医治疗“半表半里证”的疗效，采用基于数据分析，从而推断其用药规律。……