耿松 沈仲夏

[摘要] 目的 探討阿戈美拉汀治疗首发抑郁症患者的疗效及对认知功能的影响。 方法 选取2015年1月～2017年1月我院收治的首发抑郁症患者100例作为研究对象，根据治疗方法不同随机分为观察组和对照组，每组各50例，对照组予盐酸帕罗西汀，观察组予阿戈美拉汀，治疗后，对两组患者的临床疗效进行评价，同时比较两组患者治疗前后认知功能中的视空间与执行、命名、记忆、注意、语言、抽象、延迟记忆、定向各项评分。 结果 治疗后，观察组患者治疗后的总有效率为88.0%，对照组的总有效率为80.0%，两组疗效比较，差异无统计学意义（P>0.05）。治疗前，两组患者认知功能中的视空间与执行、命名、记忆、注意、语言、抽象、延迟记忆、定向评分比较，差异无统计学意义（P>0.05）。治疗后，两组患者认知功能中的视空间与执行、命名、记忆、注意、语言、抽象、延迟记忆、定向评分分别较治疗前提高，且观察组各项认知功能评分显著高于对照组，差异有统计学意义（P<0.05）。 结论 阿戈美拉汀用于首发抑郁症患者的治疗中具有显著的临床疗效，且改善患者的认知功能，提高患者的生活质量，值得临床广泛推广和应用。

[关键词] 首发抑郁症；阿戈美拉汀；盐酸帕罗西汀；认知功能

[中图分类号] R749.4 [文献标识码] B [文章编号] 1673-9701（2018）15-0114-03

Effect of agomelatine on first-episode depression and its influence on cognitive function

GENG Song SHEN Zhongxia

Department of Psychosomatic Disorders， the Third People's Hospital of Huzhou City in Zhejiang Province， Huzhou 313000， China

[Abstract] Objective To investigate the effect of agomelatine in treating first-episode depression and its influnce on cognitive function. Methods 100 patients with first-episode depression who were admitted in our hospital from January 2015 to January 2017 were selected as study subjects and randomly divided into observation group and control group with 50 cases in each group according to different treatment methods. The control group was treated with paroxetine hydrochloride and the observation group was given agomelatine. After treatment， the clinical efficacy between the two groups was evaluated. At the same time， the scores of visual space and executive， naming， memory， attention， language， abstraction， delay memory and orientation in the cognitive function between two groups before and after treatment were compared. Results After treatment， the clinical efficacy of the two groups was evaluated. The results showed that the total effective rate in the observation group and that in the control group was 88.0% and 80.0% after treatment. There was no significant difference in the total efficiency between the two groups（P>0.05）. Before treatment， there was no significant difference between the two groups in cognitive function in terms of visual space and executive， naming， memory， attention， language， abstraction， delayed memory， and directional score. After treatment， visual space and executive， naming， memory， attention， language， abstraction， delayed memory and directed score in cognitive function in two groups were significantly higher than those before treatment. And the scores of cognitive function in the observation group were significantly higher than those in the control group. There was significant difference between the groups P<0.05）. Conclusion Agomelatine has significant clinical efficacy in the treatment of patients with first-episode depression and can improve the cognitive function of patients and improve the quality of life of patients， which is worthy of widely clinical application

[Key words] First-episode depression； Agomelatine； Paroxetine hydrochloride； Cognitive function

抑郁症是一种常见的心境障碍，以显著而持久的、与处境不相称的心境低落为主要特征[1]。首发抑郁症好发病于青壮年，首次发作后在1年内30%～50%复发，严重影响患者的身心健康、社会交往、职业能力[2]。认知功能障碍是抑郁症的一个核心症状，改善抑郁症患者的认知功能有利于提高患者的社会功能，减轻社会负担[3]。传统抗抑郁药物的镇静及抗胆碱能副作用可能会加重患者的认知缺损。阿戈……