陈春香

【摘 要】 目的：观察益肾消痹丸联合针灸治疗强直性脊柱炎的效果。方法：选择强直性脊柱炎患者104例为研究对象，随机分为对照组和研究组各52例。对照组使用针灸疗法，研究组在对照组基础上给予益肾消痹丸内服。比较两组疗效、不良反应，治疗前后两组晨僵时间、全身痛和脊柱痛积分及ESR、CRP变化情况。结果：研究组总有效率明显高于对照组，治疗后晨僵时间、全身痛和脊柱痛积分均明显低于对照组，ESR、CRP明显低于对照组，差异有统计学意义（P<0.05）；两组均未出现不良反应。结论：益肾消痹丸联合针灸治疗强直性脊柱炎的效果较单纯针灸好，可有效减轻炎症反应，改善患者的临床症状，且较安全。

【关键词】 强直性脊柱炎；益肾消痹丸；针灸

【中图分类号】R593.23 【文献标志码】 A【文章编号】1007-8517（2018）06-00102-03

Abstract：Objective To observe the effect of Yishen Xiao Bi pill combined with acupuncture and moxibustion in the treatment of ankylosing spondylitis. Methods 104 patients with ankylosing spondylitis treated in our hospital were selected and randomly divided into control group and study group， 52 cases in each group. The control group was treated with acupuncture and moxibustion， and the study group was given Yishen Xiao Bi Pill on the basis of the control group. Comparison of two groups of curative effect， adverse reaction， changes of two groups before and after treatment， the time of morning stiffness， body pain and spinal pain score and ESR， CRP. Results the total efficiency of the study group was significantly higher than the control group after treatment， the time of morning stiffness， body pain and spinal pain scores were significantly lower than the control group， ESR and CRP were significantly lower than the control group， the difference was statistically significant（P<0.05）； the two groups were no adverse reactions. Conclusion Yishen Xiao Bi pill combined with acupuncture for ankylosing spondylitis is better than acupuncture alone， which can effectively reduce inflammatory reaction and improve the clinical symptoms of patients.

Keywords：Ankylosing Spondylitis； Yishen Xiao Bi pill； Acupuncture and Moxibustion

強直性脊柱炎属于自身免疫性风湿性疾病，包括周围关节及非骨性结构的病变，患者以男性居多，多发于青壮年，17～30岁为高发年龄[1]，临床表主要为腰背部疼痛、僵硬及活动受限等，部分患者表现出对称性下肢关节疼痛[2]。研究[3]发现，中医治疗该病有一定效果。笔者以益肾消痹丸联合针灸治疗强直性脊柱炎，观察其治疗效果。现报告如下。

1 资料与方法

1.1 一般资料 选择2015年2月至2017年9月于我院治疗的强直性脊柱炎患者104例为研究对象，诊断符合《中药新药临床研究指导原则》[4]中标准，有脊背痛，晨僵≥30min，伴有周围关节肿痛；排除双侧骨关节炎、伴有高血压、活动性消化道溃疡、有精神疾病及肝肾功能不全的患者。随机将患者分为对照组和研究组，各52例。其中对照组男42例，女10例；年龄20～52岁，平均（32.4±5.7）岁；病程8个月至6年，平均（3.8±1.1）年；早期21例，中期31例；中医证型：肾虚寒湿症39例，肾虚湿热症13例；……