李文莉　邓继红　张雯

[摘要] 目的 對多囊卵巢综合征（PCOS）患者胰岛素临床特征及相关因素进行探讨。 方法 方便选取该院2015年2月—2017年2月收治的PCOS患者86例进行研究，分为观察组与对照组，各43例，对照组为非胰岛素抵抗患者，观察组为胰岛素抵抗患者。对两组患者相关指标进行对比观察，分析相关因素。 结果 在体质指数、TG、HDL水平方面，观察组分别为（26.83±2.96）kg/m2、（2.26±0.42）mmol/L、（1.61±0.37）mmol/L，均明显高于对照组，差异有统计学意义（P<0.05）；在TC、LDL、P、T、E2、PRL、LH、FSH水平方面，两组差异无统计学意义（P>0.05）；在FPG、FINS、GAUC、HOMA-IR水平方面，观察组分别为（5.23±0.65）mmol/L、（18.77±10.93）mIU/L、（20.53±3.48）、（4.30±2.64），均明显高于对照组，差异有统计学意义（P<0.05）；对于PCOS胰岛素抵抗患者而言，HOMA-IR与BMI、GAUC呈正相关。结论 PCOS胰岛素抵抗患者HOMA-IR与BMI、GAUC呈正相关，降低患者葡萄糖耐量及肥胖，可使患者发病风险增加。

[关键词] PCOS；胰岛素抵抗；临床特征；相关因素

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）03（c）-0040-03

Analysis of Clinical Features and Related Factors of Insulin Resistance of Patients with Polycystic Ovary Syndrome

LI Wen-li， DENG Ji-hong， ZHANG Wen

Department of Gynecology， Kunming Maternal and Child Healthcare Hospital， Kunming， Yunnan Province， 650031 China

[Abstract] Objective To study the clinical features and related factors of insulin resistance of patients with polycystic ovary syndrome. Methods 86 cases of PCOS patients admitted and treated in our hospital from February 2015 to February 2017 were convenient selected and divided into two groups with 43 cases in each， the control group were the non-insulin resistance patients， while the observation group were the insulin resistance patients， and the related indicators were compared， and the related factors were analyzed. Results The body mass index， TG， and HDL in the observation group were respectively（26.83±2.96）kg/m2，（2.26±0.42）mmol/L，（1.61±0.37）mmol/L， which were obviously higher than those in the control group， and the differences were statistically significant（P<0.05）， and there were no obvious differences in the TC，LDL，P，T，E2，PRL，LH，FSH levels between the two groups（P>0.05）， and the FPG，FINS，GAUC，HOMA-IR levels in the observation group were respectively （5.23±0.65）mmol/L，（18.77±10.93）mIU/L，（20.53±3.48），（4.30±2.64）， which were obviously higher than those in the control group， and the differences were statistically significant（P<0.05）， and the HOMA-IR of patients with PCOS patients with insulin resistance was positively correlated with the BMI and GAUC. Conclusion The HOMA-IR of patients with PCOS patients with insulin resistance is positively correlated with the BMI and GAUC， which can decrease the glucose tolerance and obesity and increase the onset risk of patients.

[Key words] PCOS； Insulin resistance； Clinical feature； Related factor

多囊卵巢综合征，即PCOS，其特征表现为胰岛素抵抗与雄激素过多，并伴有糖代谢异常、生殖功能障碍等，属于分泌性紊乱综合征。在我国育龄女性中，PCOS的发病率在5%～10%间[1]。PCOS患者中，多数会受多种因素影响，降低机体对胰岛素的摄取，在葡萄糖利用率方面也下降，如遗传、肥胖等因素，可引起胰岛素抵抗，致使机体大量分泌胰岛素[2]。对于PCOS疾病而言，胰岛素抵抗是关键的病理变化之一，约60%～70%的PCOS患者会出现胰岛素抵抗[3]。该组针对该院2015年2月—2017年2月收治的86例PCOS患者胰岛素抵抗临床特征进行研究，分析相关影响因素，为临床诊疗提供可靠依据，现报道如下。

1 资料与方法

1.1 一般资料

方便选取该院收治的PCOS患者86例进行研究，分为观察组（胰岛素抵抗患者）与对照组（非胰岛素抵抗患者），各43例。对照组中，患者最小年龄21岁，最大35岁，平均（27.6±4.1）岁；观察组中，患者最小年龄20岁，最大35岁，平均（28.2±3.6）岁。……