周静　王鑫

[摘要] 目的 研究白三烯受體拮抗剂在成人慢性鼻-鼻窦炎鼻息肉术后中的临床疗效情况。方法 方便选择2016年5月—2017年6月在哈尔滨医科大学附属第二医院耳鼻喉科接受慢性鼻-鼻窦炎鼻息肉手术治疗的102例患者，同时基于随机数字表法进行分组，两组均包含51例患者。其中对照组组患者在手术治疗后均采用一般治疗方法，而基于以上基础，研究组则将一般治疗方法与白三烯受体拮抗剂方法进行配合，根据患者治疗后鼻内镜检查Lund-Kennedy评分情况进行评估，同时记录并发症人数，并且计算出并发症发病率。结果 根据该次调查研究结果显示，在两组患者治疗后鼻内镜检查Lund-Kennedy评估对比方面，研究组在息肉（左边2分，右边2分）、水肿（左边4分，右边2分）、鼻漏（左边1分，右边1分）等评分总分为17分，而对照组在息肉（左边11分，右边9分）、水肿（左边14分，右边12分）、鼻漏（左边6分，右边8分）等评分总分为108分，由此可见评分方面，研究组要显著低于对照组，而在并发症对比方面，其中研究组的并发症发病率要显著低于对照组，根据该次调查研究结果显示，在术后并发症对比方面，其中研究组鼻腔干燥1例，嗜睡1例，眩晕1例，并发症发生率3.92%；对照组鼻腔干燥3例，嗜睡5例，眩晕4例，并发症发生率23.53%。以上组间数据对比差异有统计学意义（P<0.05）。结论 对比各组的治疗效果方面，采用白三烯受体拮抗剂配合一般治疗可以最大程度提升患者在鼻息肉术后疗效果，降低并发症发病率，存在一定的临床推广意义。

[关键词] 白三烯受体拮抗剂；成人慢性鼻-鼻窦炎鼻息肉术；临床疗效

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2018）04（c）-0028-03

Research on Curative Effect of Leukotriene Receptor Antagonist in the Adults after the Chronic Nose-sinusitis and Nasal Polyp Surgery

ZHOU Jing1，WANG Xin2

1.Department of Otorhinolaryngology， Daqing Fourth Hospital， Daqing， Heilongjiang Province， 163412 China；Department of Otorhinolaryngology， Second Affiliated Hospital of Harbin Medical University， Harbin， Heilongjiang Province， 150086 China

[Abstract] Objective To research the curative effect of leukotriene receptor antagonist in the adults after the chronic nose-sinusitis and nasal polyp surgery. Methods 102 cases of patients with chronic nose-sinusitis and nasal polyp surgery admitted and treated in Second Affiliated Hospiatil of Harbin Medical Chiversity from May 2016 to June 2017 were conveniently selected and randomly divided into two groups with 51 cases in each， the control group used the general treatment method， while the research group used the leukotriene receptor antagonist on the basis of the control group， and the nasal endoscopy Lund-Kennedy score of patients was evaluated， at the same time， the complications number were recorded， and the morbidity of complications was calculated. Results The investigation results showed that the polyp （left 2 points and right 2 points）， edema （left 4 points and right 2 points）， and rhinorrhea （left 1 mark and right 1 points）， and the total score was 17 points in the research group， and the the polyp （left 11 points and right 9 points）， edema （left 14 points and right 12 points）， and rhinorrhea （left 6 mark and right 8 points）， and the total score was 108 points in the control group， and the scores in the research group were obviously lower than those in the control group， and the incidence rate of complications in the research group was obviously lower than that in the control group， and the investigation results showed that there was 1 case with mycteroxerosis， 1 case with somnolence and 1 case with vertigo in the research group， and the 3 cases with mycteroxerosis， 5 cases with somnolence and 4 cases with vertigo， and the difference in the incidence rate of complications between the research group and the control group was statistically significant，（3.92% vs 23.53%）（P<0.05）. Conclusion The leukotriene receptor antagonist and general therapy can improve the treatment effect of nasal polyp surgery of patients to a largest extent， and reduce the incidence rate of complications， and it is of a certain clinical promotion significance.

[Key words] Leukotriene receptor antagonist； Chronic nose-sinusitis and nasal polyp surgery in adults； Clinical curative effect

慢性鼻炎和鼻窦炎都是医院耳鼻科常见的临床病症之一，发病具有长久性与反复性的特征，而且发病人群多为成年人，而且两类疾病的发病均是因为在急性鼻炎以及鼻窦炎的早期治疗过程中未能达到预期的根治效果，而导致患者出现复发问题，最后转变为慢性病症。……