糖化血红蛋白与血脂检测在Ⅱ型糖尿病检测中的临床意义
2018-09-03耿继儒
耿继儒
[摘要] 目的 探析糖化血红蛋白与血脂检测在2型糖尿病检测中的临床意义。方法 方便选取2016年10月—2017年10月在市中医院内分泌科收治的55例2型糖尿病患者为该研究的观察组,另选取同期于该院接受治疗的55名糖耐量正常人为对照组,测定对比两组的糖化血红蛋白、血脂。结果 观察组的糖化血红蛋白水平(8.65±1.02)%、空腹血糖(7.47±0.59)mmol/L与对照组(5.18±0.66)%、(4.68±0.47)mmol/L相比差异有统计学意义(t=21.182、27.430,P<0.05);观察组患者的总胆固醇(6.45±0.46)mmol/L、甘油三酯(2.75±0.63)mmol/L、高密度脂蛋白(0.91±0.18)mmol/L、低密度脂蛋白(3.66±0.52)mmol/L与对照组相(4.45±0.55)、(1.68±0.26)、(1.42±0.35)、(2.11±0.48)mmol/L比較差异有统计学意义(t=20.686、11.643、9.610、16.243,P<0.05)。当糖化血红蛋白水平≥6.1%时,糖尿病检测的灵敏度和特异度最大。结论 糖化血红蛋白与血脂检测可对2型糖尿病患者进行早期诊断,为临床治疗方案的制定提供依据,改善预后。
[关键词] 糖化血红蛋白;血脂;2型糖尿病;临床检测价值
[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742(2018)04(c)-0183-03
Clinical Significance of Glycosylated Hemoglobin and Blood Liquid Test in Type II Diabetes
GENG Ji-ru
Department of Clinical Laboratory, Xuzhou Hospital of TCM, Xuzhou, Jiangsu Province, 221006 China
[Abstract] Objective To study the clinical significance of glycosylated hemoglobin and blood liquid test in testing the type II diabetes. Methods 55 cases of patients with type 2 diabetes admitted and treated in our hospital from October 2016 to October 2017 were convenient selected as the observation group, while 55 cases of patients with normal glucose tolerance admitted and treated in our hospital at the same period were selected as the control group, and the hemoglobin and blood liquid were compared between the two groups. Results The differences in the hemoglobin level and fasting blood glucose between the observation group and the control group were obvious[(8.65±1.02)%,(7.47±0.59)mmol/L vs (5.18±0.66)%,(4.68±0.47)mmol/L](t=21.182, 27.430, P<0.05) ; and the differences in the total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein between the observation group and the control group were statistically significant[(6.45±0.46)mmol/L,(2.75±0.63)mmol/L, (0.91±0.18)mmol/L,(3.66±0.52)mmol/L vs (4.45±0.55)mmol/L, (1.68±0.26)mmol/L,(1.42±0.35)mmol/L,(2.11±0.48)mmol/L]( t=20.686, 11.643, 9.610, 16.243, P<0.05) , and the sensitivity and specificity were the highest when the glycosylated hemoglobin ≥6.1%. Conclusion The glycosylated hemoglobin and blood liquid test can conduct the early diagnosis of patients with type II diabetes, which can provide basis for the formulation of clinical treatment plan, and improve the prognosis.
[Key words] Glycosylated hemoglobin; Blood liquid; Type II diabetes; Clinical test value
2型糖尿病约占总患病人数的90%,又称为成人型糖尿病,发病年龄多在35~40岁以后[1]。2型糖尿病患者伴随血脂异常,而血脂异常代谢是引发心血管疾病的主要危险因素。因此,对2型糖尿病患者的血脂代谢进行检测,已经逐渐成为心血管疾病预防的有效措施。此外,作为血清蛋白非酶促进糖化的产物,糖化蛋白对2型糖尿病的早期发作和检测也有着非常重要的临床意义[2-3]。该研究以2016年10月—2017年10月市中医院内分泌科收治的55例2型糖尿病患者作为研究对象,旨在探讨糖化血红蛋白与血脂检测在2型糖尿病检测中的临床意义,现报道如下。
1 资料与方法
1.1 一般资料
该次研究方便选取在市中医院内分泌科收治的55例2型糖尿病患者为该研究的观察组,其中,男30例,女25例;年龄为43~80岁,平均(62.13±2.85)岁;病程为1~8年,平均(4.05±0.98)年。另选取同期于该院接受治疗的55名糖耐量正常人为对照组,男31名,女24名;年龄为44~80岁,平均为(62.75±2.69)岁。两组基本资料对比差异无统计学意义(P>0.05),有可比性。……
