郑海红 蔡桂丽 林珍珍

[摘要] 目的 探讨天疱疮患者采取延续性护理干预对生命质量的影响效果。 方法 方便选择该院2014年1月—2017年1月收治的天疱疮患者60例作为研究对象，入组对象临床资料完整，愿意配合该研究，以入组奇偶顺序分为2组，对照组为奇数，以常规护理模式干预，研究组为偶数，在对照组基础上联合延续性护理模式干预。两组患者均随访半年以上，比较两组患者出院后服药依从率、随访半年复发率以及护理前后生活质量评分。 结果 两组患者护理前生活质量GQOL-74量表评分差异无统计学意义[（73.39±5.42）分vs （73.18±5.72）分，t=0.159 0，P=0.874 1>0.05）]，护理结束后研究组显著高于对照组[（93.22±1.64）分vs （84.39±3.21）分，差异有统计学意义（t=13.416 9，P=0.000 0<0.05）]；研究组患者出院后服药依从率高达93.33%，显著高于对照組70.00%（P<0.05）；研究组患者随访半年复发率为3.00%，显著低于对照组26.67%（χ2=6.405 2，P=0.011 4<0.05）。结论 延续性护理干预应用在天疱疮患者中能明显提高服药依从性，减少复发，提高生活质量，值得借鉴。

[关键词] 天疱疮；延续性护理；服药依从性；生活质量；复发

[中图分类号] R473.2 [文献标识码] A [文章编号] 1674-0742（2018）03（b）-0152-03

Effect of Continuous Nursing on the Quality of Life of Patients with Pemphigus

ZHENG Hai-hong， CAI Gui-li， LIN Zhen-zhen

Quanzhou Dermatology Prevention and Treatment Institute， Quanzhou， Fujian Province， 362000 China

[Abstract] Objective To study the effect of continuous nursing on the quality of life of patients with pemphigus. Methods 60 cases of patients with pemphigus admitted and treated in our hospital from January 2014 to January 2017 were conveniently selected and the objects had the complete data， and divided into two groups， the control group used the routine nursing model， while the research group used the continuous nursing model on the basis of the control group， both groups were followed up for more than half a year， and the mediation compliance， recurrence rate in half a year after follow-up， and quality of life scores before and after nursing were compared between the two groups. Results The differences in the quality of life GQOL-74 scores between the two groups before nursing each were （73.39±5.42）points vs （73.18±5.72）points，the difference was not statistically significant（t=0.159 0，P=0.874 1>0.05）， at the end of nursing， the score in the research group was obviously higher than that in the control group[（93.22±1.64）points vs （84.39±3.21）points]，the difference was statistically significant（t=13.416 9，P=0.000 0<0.05）， and the medication compliance after discharge in the research group was obviously higher than that in the control group（93.33% vs 70.00%）， the difference was statistically significant（P<0.05）， and the recurrence rate in half a year after follow-up in the research group was obviously lower than that in the control group（3.00% vs 26.67%），the difference was statistically significant （χ2=6.405 2，P=0.011 4<0.05）. Conclusion The continuous nursing intervention in patients with pemphigus can obviously improve the medication compliance， reduce the recurrence and improve the quality of life， which is worth reference.

[Key words] Pemphigus； Continuous nursing； Mediation compliance； Quality of life； Recurrence

天皰疮属于比较棘手的一组皮肤黏膜疾病，主要因表皮棘层细胞抗体沉积造成棘层细胞的松解，进而出现表皮水疱导致自身免疫性、慢性大疱性皮肤黏膜病变[1]。该病特征为皮肤成批性形成容易破裂的松弛水疱，根据皮肤损坏程度可分为四种类型，即寻常型、增殖型、落叶型及红斑型，其中寻常型最常见，而且也最严重。该病具体的病因无统一定论，某些药物可能诱发本病，或伴随肿瘤疾病而发，常见于30～50岁，加上病程缓慢，极易复发，容易导致患者全身衰竭而死亡[2]，为此需加强重视。药物治疗属于常用方案，但出院后一些患者用药依从性差，使得预后不佳，影响生活质量。为了进一步探讨天疱疮患者采取延续性护理干预对生命质量的影响效果，该文就该院2014年1月—2017年1月收治的60例患者展开了分组研究，现报道如下。