吴坚

[摘要] 目的 对静滴与口服阿奇霉素治疗儿童肺炎支原体肺炎的疗效及不良反应加以观察和对比分析。 方法 随机选取该院 2015年2月—2017年2月收治治疗的儿童支原体肺炎患儿共98例，作为该次研究的主要对象，对这些患儿实施随机分组处理，主要将患儿分为研究组和对比组两组，每组患儿49例，在对两组患儿加以治疗的时候，对比组进行阿奇霉素10 mg/（kg·d）静滴治疗的方式，在静滴治疗3 d停药4 d后，在进行第二疗程的治疗，研究组患儿口服希舒美3 d，停4 d后继续第二疗程，对两组患儿用药治疗的效果和患儿不良反应发生情况以及患儿的改善情况等方面内容加以观察和对比分析。结果 研究组患儿在进行有效治疗之后，患儿的治疗有效率为96.2%，对比组患儿治疗的总有效率为94.1%，两组患儿治疗效果比较差异无統计学意义（P>0.05），研究组患儿出现不良反应的情况比率为5.3%，对比组患儿出现不良情况的发生率为18.5%，两组患儿比较差异有统计学意义（P<0.05），同时研究组患儿在进行治疗的时候，患儿的住院时间明显要比对比组患儿少，两组患儿比较差异有统计学意义（P<0.05）。 结论 儿童支原体肺炎患儿在加以治疗的时候，使用阿奇霉素静滴停药后口服用药治疗的方式安全性相对更加显著，患儿出现的不良反应情况也相对比较少，这一治疗方式值得临床应用和有效推广。

[关键词] 静滴；口服；阿奇霉素；儿童肺炎支原体肺炎；疗效；不良反应

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）02（a）-0120-03

Efficacy and Adverse Reactions of Intravenous Azithromycin in Children with Mycoplasma Pneumoniae Pneumonia

WU Jian

Department of Pediatric， Hanjiang Hospital， Putian， Fujian Province， 351111 China

[Abstract] Objective The efficacy and adverse reactions of intravenous azithromycin and oral azithromycin in children with mycoplasma pneumoniae pneumonia were observed and compared. Methods A total of 98 cases of children with mycoplasma pneumonia were selected randomly from February 2015 to February 2017 in this hospital. As the main target of this study， these patients were randomly divided into treatment group and control group， with 49 patients in each group， were treated with azithromycin 10 mg/（kg·d） intravenously when the two groups of patients were treated. Four days after the intravenous infusion was stopped for three days， the second course of treatment， the study group of patients orally Zithromax for three days， four days after stopping the second course of treatment， the results of adverse drug reactions and patient improvement and other aspects of the content were observed and compared. Results The effective rate of treatment was 96.2% in the study group and 94.1% in the control group. There was no significant difference between the two groups in the treatment effect（P>0.05）， the incidence of adverse reactions in the study group was 5.3%， the incidence of adverse cases in the comparison group was 18.5%， the difference between the two groups was statistically significant（P<0.05）， while the study group patients in the treatment when the patients hospitalization was significantly less than the control group of patients， the difference between the two groups was statistically significant （P<0.05）. Conclusion Children with mycoplasma pneumonia in treatment， the use of azithromycin intravenous drug withdrawal after treatment is more significantly safe， patients with adverse reactions are relatively fewer， the treatment is worthy of clinical application and effective promotion.

[Key words] Static drops； Oral； Azithromycin； Child pneumonia mycoplasma pneumonia； Curative effect； Adverse reactions

支原体肺炎是儿童群体中比较常见的一种非典型肺炎疾病，这一疾病的出现主要是儿童患者的体质相对比较特殊所造成的，因此支原体肺炎主要是学龄期儿童及青少年群体中比较常见的社区获得性肺炎疾病中的一种，这一疾病在非流行年间占据小儿肺炎病原的比例已经达到10%～21%，而严重时会达到30%以上[1]。近些年来……