降钙素原对ICU发热患者血流感染的诊断及预测价值的临床研究
2018-04-12陈大洋高永友
陈大洋 高永友
【摘要】 目的:探讨降钙素原(Procalcitonin,PCT)对ICU发热患者血流感染的诊断及预测价值的临床研究。方法:选取2014年1月-2017年1月本院ICU收治的100例发热患者,根据其血流感染情况分为对照组(无血流感染,n=28)与观察组(有血流感染,n=72)。比较分析两组不同时间段血清PCT、CRP的检测结果及阳性检出率。结果:发热后12、24、36 h,观察组的PCT、CRP水平均明显高于对照组,差异均有统计学意义(P<0.05);观察组的阳性检出率明显高于对照组,差异有统计学意义(P<0.05)。结论:降钙素原对ICU发热患者血流感染的诊断有着良好的预测价值,可以作为诊断血流感染的预测指标,值得临床推广应用。
【关键词】 降钙素原; ICU发热患者; 血流感染; 诊断; 预测价值
Clinical Study of Procalcitonin in the Diagnosis and Prediction of Bloodstream Infection in Patient with ICU Fever/CHEN Dayang,GAO Yongyou.//Medical Innovation of China,2018,15(06):097-099
【Abstract】 Objective:To investigate the clinical study of the diagnostic and predictive value of procalcitonin(PCT) in patients with bloodstream infection of ICU fever.Method:100 patients with fever from January 2014 to January 2017 were selected in ICU of our hospital,and the bloodstream infection were divided into the control group(no bloodstream infection,n=28) and the observation group(bloodstream infection,n=72).The results of serum PCT,CRP and positive rate in the two groups were compared and analyzed.Result:12,24 and 36 h after fever,the levels of PCT and CRP in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The positive rate of the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Procalcitonin has a good predictive value in the diagnosis of bloodstream infection in patients with ICU fever,it can be used as a predictor of bloodstream infection and is worth popularizing in clinic.
【Key words】 Procalcitonin; ICU fever patient; Bloodstream infection; Diagnose; Predictive value
First-authors address:Yangjiang Hospital of Traditional Chinese Medicine,Yangjiang 529500,China
doi:10.3969/j.issn.1674-4985.2018.06.027
由于現代医疗技术的飞速发展,ICU内发热患者发生血流感染的可能性也在不断地增大。ICU中大部分的发热患者病情较为危重,自身对周围环境细菌感染的抵抗力较差,发热患者本身需要做一系列的检查和介入治疗[1]。因此使得ICU患者发生血流感染的风险也不断增大,对患者的生命健康安全造成了一定的威胁性。降钙素原(Procalcitonin,PCT)可以帮助患者在血流感染的早期诊断,评估感染程度和制定下一步的感染治疗方案[2]。降钙素原是人机体本身内部的一种元素,可以在预测ICU发热患者是否存在血流感染方面提供一个良好的评价指标,具有良好的临床价值[3]。本文将研究降钙素原对ICU发热患者血流感染的诊断及临床预测价值,现报道如下。
1 资料与方法
1.1 一般资料 选取2014年1月-2017年1月本院ICU收治的100例发热患者。纳入标准:(1)年龄≥18岁;(2)患者存在发热症状(体温≥38.0 ℃),且伴有寒战;(3)在患者发热24 h内完成血培养送检和PCT检测[4]。排除标准:(1)排除有血液病、肿瘤或风湿免疫性疾病的患者;(2)排除合并心、肝、肾等功能异常或不全的患者;……
