王艳

[摘要] 目的 探讨哮喘患儿肺炎衣原体（CPn）及肺炎支原体（MPn）感染的临床特征。方法 方便选取2015年6月—2017年6月该院80例哮喘患兒为研究对象，依据有无病原体感染分为实验组（CPn、MPn感染，常规治疗联合红霉素/阿奇霉素，40例）和对照组（非CPn、MPn感染，常规治疗，40例）。对比观察两组临床表现及并发症，评价疗效，观察实验组不同年龄及病程患儿的CPn、MPn感染率。结果 实验组肺炎（82.5%）、间质性肺炎（30.0%）发生率高于对照组，差异有统计学意义（P<0.05），治疗总有效率（90.0%）与对照组（92.5%）比较差异无统计学意义（P>0.05）。结论 哮喘患儿CPn、MPn感染多见于3岁以下或病程3个月以内，临床症状较非感染患者普遍严重，早期及时予以抗菌治疗效果确切，值得推广使用。

[关键词] 哮喘；肺炎衣原体；肺炎支原体；临床特征

[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2018）01（a）-0105-03

Clinical Features of Chlamydia Pneumoniae and Mycoplasma Pneumoniae Infection in Children with Asthma

WANG Yan

Department of Pediatrics， Hongquan Hospital， Yangzhou， Jiangsu Province， 225200 China

[Abstract] Objective This paper tries to investigate the clinical features of Chlamydia pneumoniae （CPn） and Mycoplasma pneumoniae（MPn） infection in children with asthma. Methods 80 cases of children with asthma from June 2015 to June 2017 were convenient selected in this hospital as the research objects， on the basis of a pathogen infection were divided into experimental group （CPn， MPn infection， conventional treatment combined with erythromycin / azithromycin， 40 cases） and control group（non CPn， MPn infection， conventional treatment， 40 cases）. The clinical manifestations and complications of the two groups were compared and the curative effect was evaluated. The infection rates of CPn and MPn in children of different ages and course of the disease were observed. Results The incidence rate of pneumonia （82.5%） and interstitial pneumonia （30.0%） in experimental group was higher than that in control group （P<0.05）， and the total effective rate （90.0%） was not significantly different from that of control group （92.5%） （P>0.05）. Conclusion CPn and MPn infection in children with asthma are more seen in 3 years old or less than 3 months. The clinical symptoms are more serious than those of non infected patients. Early treatment with antibiotics is effective and worthy of promotion.

[Key words] Asthma； Chlamydia pneumoniae； Mycoplasma pneumoniae； Clinical characteristics

哮喘是小儿常见的以反复发作性咳嗽、喘鸣、呼吸困难伴可逆性气道高反应的慢性呼吸道疾病，具有发病率高、易反复的特点，会损害肺功能，或因迁延不愈进展为成人哮喘，甚至致命，严重影响患儿身体健康及生长发育[1]。近年临床研究发现，小儿哮喘与感染存在密切相关性，CPn、MPn感染会使病情恶化，增加不良预后风险[2]。现以2015年6月—2017年6月该院收治的80例患儿为例，对哮喘伴CPn、MPn感染的临床特征进行分析和探讨，旨在为提高小儿哮喘临床诊治效果提供依据参考，现报道如下。

1 资料与方法

1.1 一般资料

方便选取该院收治的80例哮喘患儿为研究对象，依据有无病原体感染分为两组。实验组（40例）：男22例，女18例；年龄（5.0±2.7）岁；CPn感染20例，MPn感染20例。对照组（40例）：男20例，女20例；年龄（5.2±2.4）岁。……