王红霞 张相鹏 刘晓冉 曹东义

【摘 要】目的：观察泄浊解毒方治疗高尿酸血症的临床疗效。方法：将40例高尿酸血症患者随机分为治疗组和对照组，每组20例。治疗组给予泄浊解毒方口服治疗，对照组给予别嘌醇片治疗。2组均以4周为1个疗程。观察2组临床疗效，以及治疗前后血尿酸、肝肾功能、血脂等指标的变化。结果：治疗组显效2例，有效15例，无效3例，总有效率为85.00%；对照组显效1例，有效16例，无效3例，总有效率为85.00%。2组比较，差异无统计学意义（P > 0.05）。治疗后，2组血尿酸较治疗前均明显降低（P < 0.05），但2组间比较，差异无统计学意义（P > 0.05）；治疗组三酰甘油和胆固醇水平较治疗前明显降低（P < 0.05）；且肝肾功能受损较对照组轻。结论：泄浊解毒方对高尿酸血症治疗有较好作用，且无明显不良反应。

【关键词】 高尿酸血症；泄浊解毒方；血尿酸；临床疗效

【ABSTRACT】Objective：To observe the clinical efficacy of Xiezhuo Jiedu Fang（泄浊解毒方）in the treatment of hyperuricemia.Methods：Forty patients with hyperuricemia were randomly divided into a treatment group and a control group，with 20 cases in each.The treatment group was treated with Xiezhuo Jiedu Fang，while the control group was given allopurinol tablets.The two groups were treated with 4 weeks as a course.The clinical effects of two groups were observed，together with the changes of blood uric acid，liver and kidney function and blood lipid before and after treatment.Results：In the treatment group，2 cases were markedly effective，15 cases were effective，3 cases were invalid，and the total effective rate was 85.00%.In the control group，1 case was markedly effective，16 cases were effective，and 3 cases were ineffective，the total effective rate being 85.00%.The difference between the two groups was not statistically significant（P > 0.05）.After treatment，the serum uric acid in both groups was significantly lower than that before treatment（P < 0.05），and there was no significant difference between the two groups（P > 0.05）.Triglycerides and cholesterol levels in the treatment group were significantly lower than those before treatment（P < 0.05），and the damage to liver and kidney were smaller than that in the control group.Conclusion：Xiezhuo Jiedu Fang has a good effect on hyperuricemia，and there is no obvious adverse reaction.

【Keywords】 hyperuricemia；Xiezhuo Jiedu Fang（泄浊解毒方）；blood uric acid；clinical efficacy

高尿酸血症是由于嘌呤代谢异常引起的疾病，中老年男性和绝经后女性为高发人群，但有研究显示发病年龄呈年轻化趋势[1]。随着生活方式和饮食结构的改变，我国高尿酸血症人群达到了1.2亿[2]，导致痛风的发病率越来越高，给患者造成极大痛苦。临床研究表明，降低尿酸可有效改善肾损伤、非酒精性脂肪肝、高血脂、胰岛素抵抗及心血管病的发生、发展[3-5]。秦晓东等[6]研究认为，高尿酸血症能够促进颈动脉病变的发生，控制血尿酸水平对预防颈动脉病变具有重要意义。研究表明，高尿酸血症患者有一定的几率发展成为痛风，其前期状态为无症状性高尿酸血症，并逐渐发展成痛风[7]。高尿酸血症患者由于没有明显的临床症状，往往是在体检中发现。

西药治疗高尿酸血症虽然有效，但副作用大，且停药后复发率高。近……