胡礼涛++鄢富贵

[摘要]目的 分析普通手足口病患兒血清降钙素原（PCT）测定的临床意义。方法 选择我院2014年2月～2016年6月收治的手足口病患儿200例，根据病情将患儿分为普通组（110例）、重症组（60例）、病危组（30例），并选择同期健康体检儿童50例作为对照组，动态监测所有研究对象血清PCT水平，观察分析检测结果。结果 治疗前，手足口病组患儿的血清PCT水平显著高于对照组（P<0.05），且病危组患儿的血清PCT水平显著高于重症组、普通组（P<0.05）。治疗后3、7 d，手足口病组患儿的血清PCT水平均显著降低，而病危组患儿的血清PCT水平下降最显著，差异有统计学意义（P<0.05）；在预后良好率方面，普通组患儿显著高于重症组、病危组，差异有统计学意义（P<0.05）；在后遗症发生率方面，病危组显著高于普通组、重症组，差异有统计学意义（P<0.05）。结论 加强普通手足口病患儿血清PCT的监测，能对病情严重程度、病情变化情况和预后进行有效判断和控制。

[关键词]手足口病；患儿；血清降钙素原；临床意义

[中图分类号] R512.5 [文献标识码] A [文章编号] 1674-4721（2017）09（b）-0077-03

Clinical significance of serum procalcitonin measurement for children with hand-foot-and-mouth disease

HU Li-tao YAN Fu-gui

Department of Paediatrics，Ganzhou Maternal and Child Health Care Hospital，Jiangxi Province，Ganzhou 341000，China

[Abstract]Objective To analyze the clinical significance of serum procalcitonin （PCT） measurement for common children with hand-foot-and-mouth disease.Methods 200 children with hand-foot-and-mouth disease treated at our hospital from February 2014 to June 2016 were selected，according to their pathogenetic conditions，the 200 children were divided into the common group （110 patients），the severe group （60 patients） and the critically-ill group （30 patients）.Besides，50 healthy children of the corresponding period were selected as the control group.Dynamic monitoring of the changing status of all objects serum PCT level was carried out and the testing results were observed and analyzed.Results Before treatment，the serum PCT level of children with hand-foot-and-mouth disease was apparently higher than that of the control group （P<0.05），and the serum PCT level of the critically-ill group was apparently higher than that of the severe group and the common group （P<0.05）.3 and 7 days after treatment，the serum PCT level of children with hand-foot-and-mouth disease apparently decreased and the serum PCT level of the critically-ill group decreased most significantly，the difference was statistically significant （P<0.05）；in terms of the rate of favorable prognosis，the rate of the common group was apparently higher than that of the severe group and the critically-ill group，the difference was statistically significant （P<0.05）；in terms of the incidence rate of sequelae，the rate of the critically-ill group was apparently higher than that of the common group and the severe group，the difference was statistically significant （P<0.05）.Conclusion Through enhancement of monitoring serum PCT measurement for common children with hand-foot-and-mouth disease，the severity of illness，the change of patients′ condition and the prognosis can be effectively estimated and controlled.endprint

[Key words]Hand，Foot and mouth disease；Children；Serum procalcitonin；Clinical significance

手足口病是临床儿科中的多发病和常见病，年龄小于5岁的儿童是该病的主要发病人群。临床研究发现肠道病毒感染和手足口病的发生有密切关系，患儿临床表现主要为口腔、足、手等部位存在红色斑丘疹，对于重症手足口病患儿来讲，其病情会快速发展，进而对患儿的生命健康和安全造成严重影响[1]。探讨能对手足口病患儿病情严重程度和预后情况进行反映的指标，对于疾病的预防和控制非常重要。血清降钙素原（PCT）能对细菌早期感染进行有效反映，是近年来的一种热门研究指标，在对呼吸道感染性疾病患儿的临床疗效、预后等进行评估时，PCT的应用非常广泛[2-4]，然而现阶段有关PCT在手足口病中的应用价值的研究报道还比较缺乏。本研究主要分析了普通手足口病患儿血清PCT测定的临床意义，具体情况报道如下。

1资料与方法

1.1一般资料

选择我院2014年2月～2016年6月收治的手足口病患儿200例。纳入标准：均满足手足口病的相关诊断标准[5]；……