李丹丹?邹丽鑫?罗杰?张海侠?耿德红

[摘要] 目的 探討羟苯磺酸钙联合激光光凝治疗糖尿病视网膜病变的疗效。 方法 选取2015年1月～2016年10月在我院住院的治疗的Ⅲ～Ⅳ期DR患者75例65眼，所有患者随机分为对照组37例（32眼）和观察组38例（33眼），对照组给予患者激光光凝治疗，观察组在对照组基础上给予患者羟苯磺酸钙治疗。观察两组患者的临床疗效及中心30°内各刺激点光敏感度的算术平均值。观察对比两组患者术前和术后6个月视网膜新生血管荧光素渗漏面积及并发症情况。 结果 观察组患者总有效率为90.91%，明显高于对照组78.13%，两组比较差异有统计学意义（χ2=5.036，P<0.05）。观察组治疗后中心30°内平均阈值敏感度明显高于对照组，差异有统计学意义（P<0.05）。对照组治疗前后，差异无统计学意义（P>0.05）。观察组治疗后视网膜新生血管荧光素渗漏面积明显低于对照组，差异有统计学意义（P<0.05）。两组患者并发症发生率比较，差异无统计学意义（P>0.05）。 结论 羟苯磺酸钙联合激光光凝治疗糖尿病视网膜病变临床疗效显著，值得临床推广应用。

[关键词] 糖尿病视网膜病变；羟苯磺酸钙；激光光凝；前房炎症反应

[中图分类号] R587.2；R779.63 [文献标识码] A [文章编号] 2095-0616（2017）16-239-03

Curative effect of calcium dobesilate combined with laser photocoagulation on diabetic retinopathy

LI Dandan ZOU Lixin LUO Jie ZHANG Haixia GENG Dehong

Daqing Oilfield General Hospital，Daqing 163001，China

[Abstract] Objective To observe the curative effect of calcium dobesilate combined with laser photocoagulation on diabetic retinopathy. Methods 75 cases （65 eyes） with stage DR patients who were treated in our hospital from January 2015 to October-2016 were selected，all patients were randomly divided into control group of 37 cases （32 eyes） and the observation group of 38 cases （33 eyes），the control group treated with laser photocoagulation treatment，the observation group in the control group were given patients calcium dobesilate treatment.The clinical efficacy of the two groups and the arithmetic mean of light sensitivity at each stimulus point of the 30 groups were observed.The fluorescein leakage area and complications of retinal neovascularization in two groups were compared before and 6 months after operation.were compared between two groups. Results The total effective rate of the observation group was 90.91%，which was obviously higher than that of the control group，and the difference between the two groups was statistically significant （χ2=5.036，P<0.05）.The difference between the two groups was statistically significant （78.13%）.The average threshold sensitivity of the observation group was significantly higher than that of the control group at 30 degrees after the treatment，the difference was statistically significant（P<0.05）.There was no significant difference between the control group before and after treatment （P>0.05）.The fluorescein leakage area of retinal neovascularization in the observation group was significantly lower than that in the control group，the difference was statistically significant （P<0.05）.There was no significant difference in complication rate between the two groups （P>0.05）. Conclusion Calcium dobesilate combined with laser photocoagulation is effective in the treatment of diabetic retinopathy.It is worthy of clinical application.endprint

[Key words] Diabetic retinopathy；Calcium dobesilate；Laser photocoagulation；Anterior chamber inflammation

糖尿病后期最重要的眼部并發症是糖尿病视网膜病变（diabetic retinopathy，DR），如果治疗不及时可使患者致盲，因此临床必需引起足够的重视。现在临床上适宜的代谢控制治疗和光凝治疗可以使得糖尿病视网膜病变引起的失明延迟或防治[1]。但是DR一旦进入晚期将严重影响患者的生活质量，因此应尽早治疗[2-3]。本研究旨在探讨羟苯磺酸钙联合激光光凝治疗糖尿病视网膜病变的疗效，现报道如下。

1 资料与方法

1.1 一般资料

选择2015年1月～2016年10月在我院住院的治疗的Ⅲ～Ⅳ期 DR患者75例65眼，术前均行矫正视力、眼压、眼底及B超检查而确诊，均为糖尿病视网膜病变Ⅳ～Ⅵ期，排除合并严重肝肾疾病及心血管疾病患者。……