吐逊阿依·阿迪力　古丽再努·依不拉音　任家卉　尼加提·吐尔逊

[摘要] 目的 比较种植术后分别给予口服抗生素、局部使用复方氯己定含漱液、西吡氯铵含片、西帕依固龈液4种措施预防种植体术后感染的临床疗效，为未来的临床工作提供参考依据。 方法 选择2015年10月～2016年10月在新疆醫科大学第二附属医院口腔科行种植手术的患者作为研究对象，根据排除纳入标准选取48例患者，采用随机数字表法分为A、B、C、D四组，每组12例，A组在种植手术后5 d口服阿莫西林胶囊，B组在种植手术后复方氯己定含漱液漱口5 d，C组在种植手术后西帕依固龈液漱口5 d，D组种植手术后给予西吡氯铵含片5 d。通过患者疼痛感的评价，伤口愈合情况，X线片观察，牙周指数等指标评价四组药物的疗效。 结果 四组间年龄、性别、种植体部位、疼痛度、伤口愈合情况、牙龈指数、牙龈出血指数等指标差异均无统计学意义，菌斑指数差异有统计学意义（P < 0.05）。 结论 复方氯己定含漱液、西吡氯铵片、西帕依固龈液等3种局部抗菌药物可以替代抗生素有效预防种植体植入后的早期感染。

[关键词] 口腔种植；预防感染；氯己定；西吡氯铵；西帕依固龈液

[中图分类号] R782 [文献标识码] A [文章编号] 1673-7210（2017）01（c）-0125-05

[Abstract] Objective To investigate the clinical effects of oral antibiotic， local application of Compound Chlorhexidine Gargle， Cetylpyridinium Chloride Buccal Tablet and Xipayi Mouth Rinse on preventing infection after dental implant ， in order to provide reference for the future clinical work. Methods The patients were chosen from who received implant surgery in Stomatological Department， the Second Affiliated Hospital of XinJiang Medical University from October 2015 to October 2016. According to inclusion criteria， 48 patients were chosen in this study， and they were divided into A、B、C and D group by random number table， with 12 cases in each group. The group A was respectively given oral administration of amoxicillin capsules for 5 days， The group B was given Compound Chlorhexidine Gargle for 5 days， The group C was given Xipayi Mouth Rinse for 5 days， The group D was given Cetylpyridinium Chloride Buccal Tablets for 5 days. The pain assessment， wound healing， X-ray observation and periodontal index were recorded to evaluate the effect of four kinds of drugs. Results There were not statistical differences among the age， gender， implant site， pain degree， wound healing， gingival index and gingival bleeding index of patients in the four groups， while plaque index had significant different （P < 0.05）. Conclusion The local use of three kinds of antibacterial， including Compound Chlorhexidine Gargle， Cetylpyridinium Chloride Buccal Tablets and Xipayi Mouth Rinse， can replace antibiotic to prevent the early infection after dental implant effectively.

[Key words] Dental implant； Prevent infection； Chlorhexidine； Cetylpyridinium Chloride； Xipayi Mouth Rinse

随着我国口腔种植业的衍生并发展，在临床上逐渐更多的应用口腔种植技术来修复牙体缺失。与此同时关于种植失败的一系列问题引起关注，其中种植体早期发生感染是较为严重的术后并发症之一。早期感染进一步发展可对种植体与周围骨组织的结合造成影响，进而导致种植失败[1]。若种植体植入早期出现问题，更不能谈及后期修复，美学等重要指标。……