韩娟

[摘要] 目的 研究普米克令舒吸入联合阿斯美治疗感染后咳嗽的效果。 方法 选择2015年8月～2016年8月在成都市第二人民医院诊断为感染后咳嗽患者80例，采用随机数字表法将其分为A组和B组，每组40例。A组给予雾化吸入普米克令舒+口服阿斯美，B组给予口服阿斯美，疗程均为7 d。观察和分析两组治疗前后咳嗽症状评分、有效率、生活质量评分及不良反应。 结果 两组治疗后咳嗽评分均明显低于治疗前（P < 0.05），且A组治疗后咳嗽评分显著低于B组（P < 0.05）。A组总有效率（92.5%）明显高于B组（70.0%），差异有统计学意义（P < 0.05）。两组治疗后中文版莱塞斯特咳嗽生命质量问卷（LCQ）评分均明显高于治疗前（P < 0.05），且A组治疗后中文版LCQ评分显著高于B组（P < 0.05）。两组均无严重不良反应发生。 结论 普米克令舒吸入联合阿斯美口服有协同治疗感染后咳嗽的作用，疗效显著，且不良反应轻微，能明显改善患者生活质量，可安全有效地应用于临床。

[关键词] 普米克令舒；阿斯美；感染后咳嗽

[中图分类号] R56 [文献标识码] A [文章编号] 1673-7210（2017）01（c）-0152-04

[Abstract] Objective To evaluate the clinical effect of inhalation of Pulmicort respules combined with Asmeton in the treatment of post-infectious cough. Methods Eighty patients diagnosed as post-infectious cough in the Second People's Hospital of Chengdu from August 2015 to August 2016 were selected and divided into group A and group B according to the random number table， with 40 cases in each group. The group A was given inhalation of Pulmicort respules combined with oral Asmeton， the group B was given oral Asmeton， the course of the two groups was both 7 d. The cough symptoms scores， effective rates， scores of quality of life and side effects of the two groups before and after treatment were observed and analyzed. Results After treatment， the cough scores in the two groups were significantly lower than those before treatment （P < 0.05）， and the cough score after treatment in group A was lower than that in group B （P < 0.05）. After treatment， the total effective rate in group A （92.5%） was higher than that in group B （70.0%）， the difference was statistically significant （P < 0.05）. After treatment， the scores of Leicester cough questionnaire （LCQ） of Chinese version in the two groups were significantly higher than those before treatment （P < 0.05）， and the score of LCQ of Chinese version in group A was higher than that in group B （P < 0.05）. Both groups had no side effects. Conclusion Inhalation of Pulmicort respules combined with oral Asmeton has synergy effects for post-infectious cough， the effects are significant， and the side effects are light， which can significantly improve the quality of life， and can be applied in clinic safely and effectively.

[Key words] Pulmicort respules； Asmeton； Post-infectious cough

持續3～8周的亚急性咳嗽是患者就诊呼吸科的常见症状，据文献报道，40%～50%的亚急性咳嗽由感染后咳嗽导致[1]。感染后咳嗽通常继发于急性呼吸道感染，当发热、咽痛、流涕等急性期感染症状控制后，仍有刺激性干咳，或伴有少量白黏痰，严重的甚至影响患者的日常生活和工作。临床上常使用抗组胺药及镇咳药，但仍有部分患者疗效欠佳。为进一步摸索更有效的治疗方法，本研究采用普米克令舒雾化吸入联合阿斯美口服治疗感染后咳嗽，取得了满意的临床效果，现总结报道如下：

1 资料与方法

1.1 一般资料

选择2015年8月～2016年8月在成都市第二人民医院诊断为感染后咳嗽的住院患者共80例，其中男42例，女38例，年龄18～60岁。采用随机数字表法将入选患者分为A组和B组，每组40例。两组性别、年龄、病程比较差异无统计学意义（P > 0.05），具有可比性。见表1。本研究经医院医学伦理委员会批准，患者均知情同意并签署知情同意书。……