马桂平++李颖++杜娟

[摘要]目的 探讨美沙拉嗪口服联合保留灌肠治疗轻、中度溃疡性结肠炎的临床效果。方法 选取2012年4月～2014年10月在本院进行治疗的46例轻、中度溃疡性结肠炎患者作为研究对象，按照随机数字表法分成观察组（26例）和对照组（20例）。对照组给予美沙拉嗪肠溶片，观察组在对照组的基础上给予药物保留灌肠。比较两组的临床疗效以及治疗结束后的半年、1年复发率。结果 观察组的治疗总有效率为92.3%，显著高于对照组的80.0%，差异有统计学意义（P<0.05）。观察组治疗结束后的半年、1年复发率分别为12.5%、20.8%，显著低于对照组的31.3%、50.0%，差异有统计学意义（P<0.05）。结论 美沙拉嗪联合保留灌肠较单纯口服治疗轻、中度溃疡性结肠炎的临床疗效更为确切，复发率明显降低，值得临床推广应用。

[关键词]溃疡性结肠炎；美沙拉嗪；锡类散；云南白药；生肌散；保留灌肠

[中图分类号] R574.62 [文献标识码] A [文章编号] 1674-4721（2016）10（a）-0026-03

[Abstract]Objective To explore the clinical effect of oral administration of Mesalazine combined with retention enema in the treatment of mild to moderate ulcerative colitis.Methods 46 patients with mild to moderate ulcerative colitis from April 2012 to October 2014 in our hospital were selected and divided into the observation group （26 cases） and the control group （20 cases） according to the random number table method.The control group was treated with oral administration of Mesalazine.The observation group was treated with retention enema with drug on the basis of the control group.after treatment.The clinical efficacy and the recurrence rate followed up for 6 month and 1 year between the two groups was compared.Results The total effective rate of the observation group was 92.3%，which was higher than 80.0% of the control group，with significant difference （P<0.05）.The recurrence rate followed up for 6 months and 1 year of the observation group was respectively 12.5% and 20.8%，which was lower than 31.3% and 50.0% of the control group，with significant difference （P<0.05）.Conclusion The clinical effect of oral administration of Mesalazine combined with retention enema is more precise than that of a simple oral treatment in the treatment of mild to moderate ulcerative colitis，and the recurrence rate can be significantly reduced after treatment，it is worthy of clinical promotion and application.

[Key words]Ulcerative colitis；Mesalazine；Xileisan；Yunnan Baiyao；Shengjisan；Retention enema

溃疡性结肠炎是一种病变以大肠黏膜和黏膜下层为主的炎症性肠病，病变主要发生在乙状结肠和直肠，向下可延及肛门，近端可累及整个结肠，多呈慢性病程，反复发作，持续期和缓解期交替出现，临床表现以腹痛、腹泻、黏液脓血便为主，可伴有局部及全身等多种并发症[1-2]。本病可发生在任何年龄，以中青年为主，男女发病率无明显差别，目前认为，本病发病主要是由于免疫异常，同时遗传因素、感染因素、精神因素等也可能参与发病，治疗以氨基水杨酸制剂、糖皮质激素、免疫抑制剂及生物学制剂为主，近期病情均有缓解，但中远期疗效不理想，且副作用较大，增加了患者的心理负担，影响愈后[3]。近年来，我院采用美沙拉嗪口服联合锡类散、云南白药、生肌散保留灌肠治疗溃疡性结肠炎取得了满意疗效，复发率低，值得临床推广，现报道如下。……