刘远锦等

[摘要] 目的 观察康复新液保留灌肠联合口服美沙拉嗪治疗溃疡性结肠炎的效果。 方法 将本院2011年1月～2013年12月收集的符合入选标准的60例溃疡性结肠炎患者随机分为治疗组和对照组各30例，治疗组给予康复新液100 ml保留灌肠，取膝胸卧位20 min，1次/d，1个月为1个疗程，并口服美沙拉嗪1 g/次，4次/d，治疗1个月后行结肠镜检查，根据病情继续用美沙拉嗪维持治疗1个月。对照组口服美沙拉嗪1 g/次，4次/d，1个月为1个疗程，共2个疗程。半年后行结肠镜检查。 结果 治疗组完全缓解22例（73.3%），有效5例（16.7%），无效3例（10.0%），总有效率为90.0%；对照组完全缓解7例（23.3%），有效12例（40.0%），无效11例（36.7%），总有效率为63.3%；两组总有效率比较，差异有统计学意义（P<0.05）。治疗组治疗后临床症状体征缓解率、内镜下结肠黏膜病变恢复正常率、内镜下活检组织病理恢复正常率均高于对照组，差异有统计学意义（P<0.05）。 结论 康复新液保留灌肠联合口服美沙拉嗪治疗溃疡性结肠炎操作简便，效果较好，在治疗活动期溃疡性结肠炎中值得推广。

[关键词] 溃疡性结肠炎；康复新液；保留灌肠；效果

[中图分类号] R975 [文献标识码] A [文章编号] 1674-4721（2015）01（b）-0085-03

Effect observation of Kangfuxin solution for retention enema combined with oral administration of mesalazine in the treatment of ulcerative colitis

LIU Yuan-jin1 CHEN Ming-song1 LU Zhi-yi1 HUANG Ren-ai2

1.Department of Gastroenterology，Traditional Chinese Medicine Hospital of Nankang District in Ganzhou City of Jiangxi Province，Ganzhou 341400，China；2.Endoscope Room，Traditional Chinese Medicine Hospital of Nankang District in Ganzhou City of Jiangxi Province，Ganzhou 341400，China

[Abstract] Objective To observe the effect of Kangfuxin solution for retention enema combined with oral administration of mesalazine in the treatment of ulcerative colitis. Methods 60 patients with ulcerative colitis meeting the criteria in our hospital from January 2011 to December 2013 were evenly divided into treatment group and control group in random.In the treatment group，100 ml Kangfuxin solution for retention enema in knee-chest position once per day and one course of treatment lasted one month.Besides，1 g mesalazine for oral administration was provided in each time，four times per day.After one-month treatment，colonoscopy was used.Based on the disease condition，mesalazine was continued for another one month.In the control group，1 g mesalazine for oral administration each time and four times per day was applied.One course of treatment lasted one month，in two courses of treatment.The colonoscopy was used half a year later. Results In the treatment group，complete remission were 22 cases （73.3%），partial remission were 5 cases （16.7%），and invalidity were 3 cases （10.0%），the total effective rate was 90.0%.In the control group，complete remission，partial remission，and invalidity were 7 cases （23.3%），12 cases （40.0%），and 11 cases （36.7%） respectively，the total effective rate was 63.3%.There was significant difference of the total effective rate between the two groups （P<0.05）.Remission rate of clinical symptoms and signs，the rate of endoscopic colon mucosal lesions returned to normal，the rate of endoscopic biopsy histopathology returned to normal in the treatment group was higher than that of control group，the difference was significant （P<0.05）. Conclusion Kangfuxin solution for retention enema combined with oral administration of mesalazine in the treatment of ulcerative colitis has the advantages of easy performance and favorable effect，and is worthy of expansion at active stage.

[Key words] Ulcerative colitis；Kangfuxin solution；Retention enema；Effect

溃疡性结肠炎是一种病因不明的直肠和结肠慢性非特异性炎症性疾病[1-3]。病理改变局限于大肠黏膜与黏膜下层，病变部位多位于乙状结肠及直肠，也可延伸至降结肠，甚至整个结肠。病程较长，常反复发作，难以彻底治愈，青年人发病多见。临床表现为腹泻、黏液脓血便、腹痛。本科应用康复新液保留灌肠联合口服美沙拉嗪治疗溃疡性结肠炎，取得了较好的疗效。

1 资料与方法

1.1 一般资料

选取2011年1月～2013年12月赣州市南康区中医院活动期溃疡性结肠炎60例，随机分为治疗组和对照组。治疗组30例，男性12例，女性18例，年龄24～62岁，中位年龄50.1岁，病程10个月～8年；对照组30例，男性13例，女性17例，年龄27～63岁，中位年龄48.6岁，病程8个月～6年；两组患者的性别、年龄、病程等资料差异无统计学意义（P>0.05），具有可比性。……