冯德霞　张海霞

[摘要] 目的 探讨锡类散与美沙拉嗪缓释颗粒剂联合保留灌肠治疗宫颈癌放射性直肠炎的效果。 方法 将86例患者随机分为治疗组和对照组，每组各43例，对照组采用常规小牛血去蛋白提取物注射液静脉滴注与蒙脱石散剂口服治疗，治疗组在对照组的基础上，采用锡类散与美沙嗪缓释颗粒剂保留灌肠。 结果 治疗组患者的总有效率为100.0%，对照组为74.4%，治疗组明显优于对照组，差异有统计学意义（P<0.05）。 结论 锡类散与美沙拉嗪联合保留灌肠治疗宫颈癌放射性直肠炎的效果明确。

[关键词] 锡类散；美沙拉嗪缓释颗粒剂；放射性直肠炎；宫颈癌；保留灌肠

[中图分类号] R737.33 [文献标识码] A [文章编号] 1674-4721（2014）08（b）-0054-03

[Abstract] Objective To discuss the effect of retention enema with Xilei powder and mesalazine slow-release granules to the radiation proctitis patients of the uterine cervix cancer. Methods 86 patients were randomly divided into treatment group and control group，each group of 43 cases，the control group were treated with drip protein-free calf blood extract injection and oral smectite powder，besides which the treatment group added retention enema with Xilei powder and mesalazine slow-release granules. Results The total effective rate of patients in the treatment group was 100.0%，while the control group was 74.4%，the curative effect in treatment group was better than that of the control group，the difference was statistically significant （P<0.05）. Conclusion The retention enema with XilLei powder and mesalazine slow-release granules have a certain effect to the radiation proctitis patients of the uterine cervix cancer.

[Key words] Xilei powder；Mesalazine slow-release granule；Radiation proctitis；Uterine cervix cancer；Retention enema

宫颈癌是最常见的女性生殖道恶性肿瘤，我国宫颈癌发病率及死亡率占全世界的1/3，严重威胁妇女的生命[1]，宫颈癌的治疗方法以手术和放疗为主，手术主要适用于早期（0～Ⅱa期），而放疗可用于各期浸润癌，尤其是晚期宫颈癌患者[2]。放射性直肠炎是指接受盆腔放疗后的患者出现的下腹痛、腹泻、下坠感，甚至有里急后重或脓血便，直肠镜检查见直肠黏膜充血、出血、糜烂、溃疡。一般分为急性和慢性直肠炎两大类型，急性直肠炎多发生在放疗期间，尤以腔内放疗后多见。放射性直肠炎是宫颈癌放疗后常见并发症，有文献报道，其发生率高达80%[3-4]以上，严重影响宫颈癌放疗后患者的生活质量和生存率，目前尚无特效治疗方法，主要是对症治疗。有文献报道，混合液保留灌肠对宫颈癌放疗后所致的迟发性放射性直肠炎的疗效较好[5-6]，本科采用锡类散联合美沙拉嗪缓释颗粒剂保留灌肠治疗宫颈癌放射性直肠炎，取得较好的效果。……