姜 炎 牛延良 王利军



分析丙戊酸钠缓释片治疗老年癫痫患者的临床疗效

姜 炎 牛延良 王利军

【摘要】目的 分析讨论丙戊酸钠缓释片治疗老年癫痫患者的临床疗效。方法 2013年5月～2015年10月，我院接收老年癫痫患者共计147例，根据治疗方法不同进行随机分配，73例患者选择苯巴比妥治疗，为对照组，74例患者选择丙戊酸钠缓释片，为观察组，比较治疗效果。结果 对照组患者治疗后疗效、住院时间、不良反应发生率分别为71.23%、（26.80±0.65）d、34.25%，观察组患者分别为97.30%、（18.70±0.49）d、8.11%，观察组HAMD评分为（8.20±1.96）分，对照组为（11.50±2.39）分，ADL分别为（20.00±2.27）分、（23.00±1.73）分，差异具有统计学意义（P＜0.05）。结论 对于老年癫痫患者，临床予以丙戊酸钠缓释片给药治疗，可有效降低患者发病频率，且用药安全性较高。

【关键词】丙戊酸钠缓释片；老年癫痫；临床疗效

Objective To discuss the clinical effect of sodium valproate in treating elderly patients with epilepsy. Methods From May 2013 to October 2015 period，our hospital received 147 cases of elderly patients with epilepsy. According to the different methods of treatment，73 patients as the control group were used phenobarbital，74 patients as observation group were used propionate sodium valproate sustained-release tablets，compared the therapeutic effect. Results After treatment，efficacy，length of hospital stay，incidence of adverse reactions in the control group were 71.23%，（26.80±0.65）days，34.25%，the observation group was 97.30%，（18.70±0.49）days，8.11%. HAMD score of observation group （8.20±1.96）points，the control group was （11.50±2.39）points，ADL respectively were （20.00±2.27）points，（23.00±1.73）points，the difference was statistically significant（P＜0.05）. Conclusion For elderly patients with epilepsy，valproate sustained-release tablets to be administered in clinical treatment，it can effectively reduce the frequency of onset and higher drug safety，the proposed promotion.

【Key words】 Sodium valproate，Elderly epilepsy，Clinical efficacy

癫痫俗称羊癫疯，在我国的临床发病率较高，是最为常见的神经系统疾病之一，其发病机制为中枢神经原有的抑制与兴奋平衡被破坏，可能与遗传因素相关，基因突变后导致离子通道功能改变，造成部分蛋白缺陷，诱发疾病，此外，若神经递质传递受限或过度，导致兴奋与抑制失衡，进而产生癫痫性放电，另外有临床研究表明，神经胶质细胞异常同样可能破坏神经元微环境的原有平衡，诱发疾病［1］。除了遗传因素外，颅内肿瘤、脑炎、弓形虫感染、脑脓肿、脑外伤、各种脑血管病变、结节性硬化、脑畸形、大脑灰质异位症等均有可能诱发癫痫。该病绝大多数患者发作时能被控制，部分患者经过系统治疗后可痊愈。……