区贵英

[摘要] 目的 探讨吸入型糖皮质激素治疗急性哮喘发作患儿的效果。 方法 选取本院2014年3月～2015年3月收治的92例急性哮喘发作患儿作为研究对象，随机分为治疗组和对照组，各46例。两组均吸入支气管舒张剂，在此基础上，治疗组行氧动雾化吸入法吸入布地奈德，对照组行氧动雾化吸入法吸入生理盐水。比较两组治疗前及治疗后0、1、2 h的心率、肺通气功能、呼吸频率、临床症状评分和血氧饱和度情况。 结果 两组治疗后0、1、2 h的FEV1、FEV1%、呼吸频率、临床症状评分、血氧饱和度水平与治疗前比较，差异有统计学意义（P<0.05）。治疗组治疗后2 h的临床症状评分显著低于对照组，差异有统计学意义（P<0.05）。治疗组治疗后各时间段的缓解情况、全身使用糖皮质激素和住院情况显著优于对照组，差异有统计学意义（P<0.05）。 结论 支气管舒张剂与糖皮质激素可起到协同作用，不仅能够缓解急性哮喘发作患儿的病情，还可以促进肺功能恢复正常，降低住院率及全身糖皮质激素使用率。

[关键词] 吸入型；糖皮质激素；急性哮喘

[中图分类号] R725.6 [文献标识码] A [文章编号] 1674-4721（2016）02（b）-0134-03

Effect analysis of inhaled glucocorticoid in the treatment of children patient with acute asthma

OU Gui-ying

Department of Pediatrics，Traditional Chinese Medicine Hospital of Xinxing County of Yunfu City in Guangdong Province，Xinxing 527400，China

[Abstract] Objective To explore the effect of inhaled glucocorticoid in the treatment of children patient with acute asthma. Methods 92 asthma children patient from March 2014 to March 2015 in our hospital were selected and randomly divided into the treatment group and the control group，46 cases in each group.All patients were treated with inhalation bronchi relaxation.On the basis of that，the treatment group was treated with oxygen atomizationatomized inhalation for inhalation of budesonide，the control group was given oxygen atomization atomized inhalation for inhalation of normal saline.Heart rate，pulmonary ventilation function，respiratory rate，clinical symptom score and saturation of blood oxygen before treatment and 0，1，2 h after treatment in the two group was compared respectively. Results There was significant difference in the level of FEV1，FEV1%，respiratory rate，clinical symptom score and blood oxygen saturation between 0，1，2 h after treatment and before treatment （P<0.05）.The score of clinical symptom after treatment for 2 h in the treatment group was lower than that in the control group，with significant difference （P<0.05）.Remission situation of all stage，hospitalization situation and using rate of systemic corticosteroid in the treatment group was better than that in the control group，with significant difference （P<0.05）. Conclusion Bronchi relaxation and glucocorticoid has synergistic effect，which not only can relieve the disease of acute asthma children patient，but also can promote lung function recovery，reduce hospitalization rate and use rate of systemic glucocorticoid.

[Key words] Inhalation；Glucocorticoid；Acute asthma

支气管哮喘是一种慢性炎性呼吸道疾病，多发于儿童群体，临床表现为炎性细胞浸润、上皮损伤、微血管渗出增加、通透性增加，同时可伴有平滑肌痉挛等[1]。如果不能及时发现和治疗本病，则会给儿童生命构成威胁。临床常采用糖皮质激素治疗支气管哮喘，但会引发多种不良反应。本研究选取本院的急性哮喘发作患儿作为研究对象，采用吸入型糖皮质激素治疗，取得了较满意的效果。

1 资料与方法

1.1 一般资料

选取2014年3月～2015年3月本院收治的92例急性哮喘发作患儿作为研究对象，所有患儿均符合《儿童支气管哮喘防治常规（试行）》[2]标准。将入选患儿随机分为治疗组和对照组，各46例。治疗组中，男24例，女22例；年龄6～14岁，平均（8.23±3.17）岁。对照组中，男26例，女20例；年龄6～15岁，平均（8.87±3.42）岁。治疗前曾用过糖皮质激素，药物过敏，危重哮喘发作，严重肾脏、肝脏、心脏和肺疾病患儿均被排除。……