刘 薇



丙泊酚及右美托咪定用于妇产科手术麻醉的镇静效果比较

刘 薇

【摘要】目的 比较丙泊酚和右美托咪定在妇产科手术麻醉的镇静效果。方法 研究2015年1～10月纳入妇产科手术48例，按数字法将其分组。手术麻醉应用丙泊酚者24例（对照组）；应用右美托咪定者24例（研究组），对比两组。结果 两组中研究组镇静评分较优，不良反应率低，差异具有统计学意义（P＜0．05）。结论 妇产科手术麻醉应用右美托咪定，镇静效果佳。

【关键词】妇产科手术；麻醉；丙泊酚；右美托咪定；镇静效果

Objective Sedative effects of propofol and dexmedetomidine in application of obstetrics and gynecology operation anesthesia are to be comparatively studied． Methods Chose 48 patients who were given obstetrics and gynecology operation in hospital from January 2015 to October 2015 and separated them into two groups according to digits，24 patients in control group were applied with propofol in operation anesthesia，while another 24 patients in study group were applied with dexmedetomidine in operation anesthesia，and then compared sedative effects of propofol and dexmedetomidine between two groups． Results Sedative effect of dexmedetomidine was much better and side-effect incidence in study group was lower than that in control group，there was a differential between two groups and such a differential had statistic value（P＜0．05）． Conclusion Dexmedetomidine is much more sedative effectively in application of obstetrics and gynecology operation anesthesia．

【Key words】 Obstetrics and gynecology operation，Anesthesia，Propofol，Dexmedetomidine，Sedative effects

妇产科手术者应激强烈，易引起不安、抑郁、紧张、烦躁及焦虑等，影响操作。手术麻醉中应用镇静药物，可促使生命体征稳定，缓解不安等情绪，确保手术操作顺利实施。此文研究2015 年1～10月纳入妇产科手术48例，比较分析丙泊酚和右美托咪定镇静效果，具体见下。

1 资料和方法

1.1 一般资料

研究2015年1～10月纳入妇产科手术48例，按数字法将其分组。手术麻醉应用丙泊酚者24例，入对照组，年龄22～47岁，平均（30.29±2.44）岁，ASA分级：14例Ⅰ级，10例Ⅱ级。应用右美托咪定者24例，入研究组，年龄22～48岁，平均（30.11±2.78）岁，ASA分级：15例Ⅰ级，9例Ⅱ级。组间差异不具有统计学意义（P＞0.05）。

1.2 方法

取复方乳酸钠给予静脉输注，500 ml，于L2-3间隙穿刺，放置硬膜外导管，约3 cm；先取利多卡因3 ml，观察有无血压下降及呼吸麻痹，后取利多卡因15 ml，按1 ml/s通过硬膜外导管注射；协助摆放平卧位，各项指标稳定后，对其麻醉平面进行测量，麻醉平面应＞8 T水平，并给氧。（1）对照组麻醉：取丙泊酚，按60 µg/kg•min泵注，BIS70-80，用药15 min后开始手术；手术结束之前5～10 min，停止泵注。……