检测子宫内膜异位症患者血清与腹腔液催乳素和皮质醇的临床意义*

王景1袁素华2李小梅1梁燕梅3刘霞1郭雯雯1

(1.肇庆医学高等专科学校, 广东 肇庆 526020；2.雅安职业技术学院, 四川 雅安 625000；3.高要市人民医院, 广东 肇庆 526020)

【摘要】目的探讨子宫内膜异位症(EM)患者催乳素(PRL)和皮质醇(COR)的表达水平，并分析其临床意义。方法采用化学免疫发光分析法，检测66例EM(EM组)患者及29例行腹腔镜手术的非EM患者(对照组)血清及腹腔液中PRL和COR浓度。66例EM患者严格按照AFS修正的分期法分为Ⅰ、Ⅱ、Ⅲ、Ⅳ期。其中轻度组(Ⅰ/Ⅱ期)31例；重度组(Ⅲ/Ⅳ期)35例；又根据有无妊娠分为：EM无妊娠者41例(不孕组)和EM有妊娠者25例(妊娠组)；EM无痛经者17例(非痛经组)和EM有痛经者49例(痛经组)。进行EM严重程度、合并不孕及合并痛经的相关性分析。结果血清PRL和COR水平，EM组中的轻度组和重度组与对照组比较，有显著性差异(P<0.05)。血清PRL和COR浓度在不孕组显著高于妊娠组，在痛经组显著高于非痛经组(P<0.05)。腹腔液中PRL和COR的变化没有统计学意义(P>0.05)。结论血清中的皮质醇和PRL水平与EM、EM合并不孕、EM合并痛经密切相关。

【关键词】子宫内膜异位症； 不孕； 痛经； 催乳素； 皮质醇

【中图分类号】R 711.71

【文献标志码】A

doi：10.3969/j.issn.1672-3511.2015.10.032

Abstract【】ObjectiveTo explore the cortisol and prolactin levels in serum and peritoneal fluid in endometriosis and analyze the significance.MethodsProlactin and cortisol in serum and peritoneal fluid were detected in 66 EM patients and 29 normal women by Chemical luminescence immune analysis method. According strictly to the AFS installment method of correction, 66 EM patients can be divided into three phases: Ⅰ,Ⅱ,Ⅲ and Ⅳ. According to the state of a pregnancy, the patients were divided into EM without pregnancy (infertility group) and EM with pregnancy (pregnancy group). According to the state of dysmenorrheal, the patients were divided into EM without dysmenorrhea (painless group) and EM with dysmenorrhea (pain group). The correlational analyses were conducted among EM severity, merge infertility and merge dysmenorrheal. The correlation analysis between Prolactin and cortisol in Serum and Endometriosis, endometriosis associated infertility and endometriosis associated dysmenorrhea were performed with Pearson analysis.ResultsThe serum PRL and COR of EM group were significantly different from that of control group(P<0.05). The serum PRL and COR of infertility group were higher than that of pregnancy group (P<0.05). The PRL and COR of peritoneal fluid were not statistical significant different (P>0.05).ConclusionThe level of cortisol in the serum correlated to the Endometriosis，endometriosis associated infertility and endometriosis associated Dysmenorrhea.

基金项目：广东省肇庆市科技创新计划项目(2014E135)

通讯作者：袁素华，E-mail:457482895@qq.com

收稿日期：( 2015-04-01； 编辑： 陈舟贵)

ClinicalsignificanceofdeterminationofcortisolandprolactinlevelsinserumandperitonealfluidinendometriosisWANGJing1，YUAN Suhua2，LI Xiaomei1，et al

(1.Zhaoqing Medical College, Zhaoqing 526020, Guangdong, China；

2.Ya’an Vocational College, Ya’an 625000, Shanxi, China；

3.Gaoyao People’s Hospital, Zhaoqing 526020, Guangdong, China)

【Keywords】Endometriosis；EM；Infertility；Dysmenorrhea；Prolactin；Cortisol

子宫内膜异位症(endometrosis，EM)是育龄期妇女常见病，发病率高且有逐年上升的趋势[1]。EM的特征是有活性的子宫内膜组织在子宫内膜以外的部位出现、生长、浸润。其典型表现为痛经、月经失调、性交困难、无周期性盆腔疼痛、无排卵、黄体功能低下、流产和不孕等临床症状。其中痛经和不孕是主要的并发症[2]。而EM的病因和发病机制至今尚不明确。……