血浆同型半胱氨酸水平与冠状动脉慢血流现象的相关性
2015-01-05马伟利
马伟利
[摘要] 目的 探讨比较血浆同型半胱氨酸(HCY)水平与冠状动脉慢血流现象的相关性。方法 资料随机选取2011年11月—2013年11月该院收治的240例临床表现为胸痛患者,患者均行冠状动脉造影检查,按照检查结果分为两组,对照组120例患者冠脉造影检查结果正常,研究组120例出现冠脉慢血流情况,分别测定两组患者的血浆HCY水平、血脂、C反应蛋白等相关性指标,分析患者冠状动脉病变支数及狭窄程度。结果 研究组患者HCY(21.56±2.46)mmol/L、血清Cys C(1.65±0.49)mmol/L水平明显高于对照组,且随着患者的病情加重而不断升高,患者CRP(58.63±37.03)ng/L、TG(2.52±1.53)mmol/L及LDL(7.80±0.46)mmol/L等检验结果均明显高于对照组,比较差异有统计学意义(P<0.05)。 结论 血浆HCY水平升高提示冠状动脉出现慢血流现象,可作为临床冠状动脉临床病变的独立危险因素。
[关键词] 血浆;同型半胱氨酸; 冠状动脉慢血流;相关性
[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-0742(2014)10(b)-0022-03
Correlation Between Plasma Homocysteine Levels and Coronary Slow Flow Phenomenon
MA Weili
Cardiovascular Department, Chaoyang Central Hospital, Chaoyang, Liaoning Province, 122000, China
[Abstract] Objective To compare the correlation between plasma homocysteine (HCY) level and coronary slow flow phenomenon. Methods The data of 240 cases with chest pain admitted in our hospital from November 2011 to November 2013 were randomly selected. All the patients underwent coronary angiography. And according to the results of the examination, the patients were divided into two groups. Patients in the control group had normal results of coronary angiography, and patients in the study group had coronary slow flow. Plasma HCY levels, blood lipids, C-reactive protein and other related indicators were measured in both groups. And the number and stenosis degree of affected coronary artery branches in the patients were analyzed. Results The HCY and serum Cys C level of the study group was (21.56 ± 2.46) mmol/L, (1.65±0.49)mmol/L, respectively, obviously higher than that of the control group, respectively, and those increased along with the severity of the disease; the examination results of CRP, TG, LDL level was (58.63±37.03)ng/L, (2.52±1.53)mmol/L, (7.80±0.46)mmol/L, respectively, significantly higher than that of the control group, respectively, the differences were statistically significant(P<0.05). Conclusion Elevated plasma HCY levels suggest that coronary slow flow phenomenon occurs, which can be used as an independent risk factor of clinical coronary artery lesions.
[Key words] Plasma; Homocysteine; Coronary slow flow; Correlation
同型半胱氨酸属于人体机体内部循环能量产生的代谢产物,作为临床冠状动脉病变的危险因素,其在临床早期诊断过程中可作为临床诊断指标,提示患者粥样硬化及血管损伤等情况出现[1]。该研究中针对该院2011年11月—2013年1月收治的240例临床表现为胸痛患者予以冠状动脉造影检查,与血检结果结合进行综合性分析,现报道如下。
1 资料与方法
1.1 一般资料
资料随机选取该院收治的240例临床表现为胸痛且行冠脉造影检查患者,按照检查结果分为对照组和研究组,每组120例;对照组检查结果较为正常,未出现冠状动脉慢血流情况,男女比例62:58,年龄42~73岁,平均(57.7±3.8)岁;研究组检查结果出现冠状动脉慢血流情况,男女比例65∶55,年龄44~71岁,平均(56.4±3.5)岁。endprint
1.2 纳入与排除标准……p>
