余燕红+陈影+梁燕芬

广东省肇庆市第二人民医院，广东肇庆 526040

[摘要] 目的 探讨降钙素原（PCT）在脓毒血症患儿早期预后预测的应用价值，以期为脓毒血症患儿疾病的诊断治疗提供依据。 方法 2012年10月～2013年10月肇庆市第二人民医院收治的脓毒血症患儿以及同期40例非脓毒血症患儿（非脓毒血症组）为研究对象，其中60例脓毒血症患儿为脓毒血症组，根据患病性质分为细菌性脓毒血症组（40例）、非细菌性脓毒血症组（20例）；60例脓毒血症患儿中治疗痊愈的为存活组，死亡的为死亡组。根据新生患儿危重病例（NCIS）评分法对60例脓毒血症患儿患病程度进行评定；检测细菌性脓毒血症组、非细菌性脓毒血症组以及非脓毒血症组患儿的血清PCT、白细胞（WBC）、C反应蛋白（CRP）水平，并对数据进行统计分析。 结果 60例脓毒血症患儿入院治疗痊愈的41例（存活组），死亡19例（死亡组）；细菌性脓毒血症组、非细菌性浓度血症组血清PCT水平[（11.86±5.92）、（2.14±1.33） ng/mL]和非脓毒血症组的血清PCT水平[（0.37±0.22） ng/mL]相比，差异有统计学意义（P < 0.05），细菌性脓毒血症血清PCT水平与非细菌性脓毒血症组相比，差异有统计学意义（P < 0.05）；脓毒血症组WBC水平[（13.7±1.5）×109/L]和非脓毒血症组患儿WBC水平分[（12.9±1.9）×109/L]相比，差异无统计学意义（P > 0.05）。1例患儿NCIS评分为非极危重，其血清PCT水平则超过14.86 ng/mL患儿最后死亡；NCIS评分为极危重患儿6例，其血清PCT水平未超过14.86 ng/mL，治疗后患儿存活。 结论 血清PCT在脓毒血症患儿早期预后预测具有显著的应用价值。

[关键词] 降钙素原；脓毒血症；预后；预测；应用

[中图分类号] R978.1 [文献标识码] A [文章编号] 1673-7210（2014）03（b）-0044-04

Application value of procalcitonin on early prediction of insepsis patients

YU Yanhong CHEN Ying LIANG Yanfen

The Second People's Hospital of Zhaoqing City， Guangdong Province， Zhaoqing 526040， China

[Abstract] Objective To investigate the application value of procalcitonin on early prediction of insepsis patients， in order to provide the basis for the diagnosis and treatment of disease in children with sepsis. Methods From October 2012 to October 2013， in the Second People's Hospital of Zhaoqing City， 60 cases of children with sepsis （sepsis group） and 40 cases of non-sepsis（non-sepsis group） in the same period were selected， and the 60 cases of children with sepsis were divided into bacterial sepsis group （40 cases）， non bacterial sepsis group （20 cases）； 60 cases of children cured were as survival group， and children died were as death group. According to the newborn children with critical cases （NCIS） evaluation method was to assess how sick children were. The serum PCT， the WBC and CRP levels of three groups （bacterial sepsis group， non bacterial sepsis group and non sepsis group） were detected， and these date were statistical analyzed. Results 60 cases of children with sepsis cured were 41 （survival group）， died were 19 （death group）； the serum PCT levels of bacterial sepsis group and non bacterial sepsis group [（11.86±5.92）， （2.14±1.33） ng/mL] were compared with that of non sepsis group [（0.37±0.22） ng/mL]， the differences were statistically significant （P < 0.05）； the serum PCT level of bacterial sepsis group was cmopared with that of non bacterial sepsis group， the differences were statistically significant （P < 0.05）； the WBC level of sepsis groups [（13.7±1.5） ×109/L] was compared with that of non sepsis groups [（12.9±1.9） ×109/L]， the difference was not statistically significant （P > 0.05）. 1 case with non severe sepsis NCIS score， whose the serum PCT level was more than 14.86 ng/mL， was finally died； while 6 cases with severe sepsis NCIS score， whoes the serum PCT levels were less than 14.86 ng/mL， were survival. Conclusion The serum PCT in children with sepsis early prognosis prediction has significant application value.

[Key words] Procalcitonin； Sepsis； Prognosis； Predict； Application

脓毒血症是一种常见的疾病，由真菌或细菌侵入患儿血液，并在其中生长、繁殖产生毒素引起全身感染的病症，是患儿常见的致死病因[1]。……