胡晓俊 鲍玲梅

【摘要】 目的：探讨胃灵颗粒对胃溃疡（GU）患者幽门螺杆菌（Hp）根除率、表皮生长因子（EGF）、前列腺素E2（PGE2）的影响。方法：选择2021年1月—2023年7月宜都市人民医院103例GU患者，随机分为观察组50例和对照组53例。两组均接受规范抗Hp的四联疗法，观察组在此基础上口服胃灵颗粒，两组均治疗14 d。比较临床疗效、Hp根除率、EGF和PGE2水平，以及药物不良反应。结果：观察组总有效率为100%，高于对照组的86.79%（P<0.05）。观察组Hp根除率高于对照组（P<0.05）。治疗后，观察组EGF、PGE2水平均高于对照组（P<0.05）。两组不良反发生率比较，差异无统计学意义（P>0.05）。结论：胃灵颗粒治疗GU能提高Hp感染根除率，促进胃黏膜分泌EGF、PGE2，增强胃黏膜修复功能，疗效显著。

【关键词】 胃溃疡 胃灵颗粒 幽门螺杆菌 表皮生长因子 前列腺素E2

Effects of Weiling Granules on Hp Eradication Rate， EGF and PGE2 in Patients with Gastric Ulcer/HU Xiaojun， BAO Lingmei. //Medical Innovation of China， 2024， 21（13）： -112

[Abstract] Objective： To investigate the effects of Weiling Granules on Helicobacter pylori （Hp） eradication rate， epidermal growth factor （EGF） and prostaglandin E2 （PGE2） in patients with gastric ulcer （GU）. Method： A total of 103 patients with GU who were admitted to Yidu People's Hospital between January 2021 and July 2023 were selected as the research subjects， they were randomly divided into the observation group 50 cases and the control group 53 cases. Both groups of patients were treated with standard anti-Hp quadruple therapy， the observation group was treated with oral Weiling Granules on this basis， and both groups were treated for 14 days. The clinical effect， Hp eradication rate， levels of EGF and PGE2， and adverse drug reactions were compared between the two groups. Result： The total effective rate in the observation group was 100%， which was higher than 86.79% in the control group （P<0.05）. Hp eradication rate in the observation group was higher than that in the control group （P<0.05）. After treatment， the levels of EGF and PGE2 in the observation group were higher than those in the control group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion： Weiling Granules can improve the Hp eradication rate and promote the secretion of EGF and PGE2 from gastroduodenal mucosa， and enhance the gastric mucosa repair function， with obvious effect.

[Key words] Gastric ulcer Weiling Granules Helicobacter pylori Epidermal growth factor Prostaglandin E2

First-author's address： Department of Gastroenterology， Yidu People's Hospital， Yidu 443300， China

doi：10.3969/j.issn.1674-4985.2024.13.025

胃溃疡（gastric ulcer，GU）与情绪波动、药物作用、不健康生活习惯等多种致病因素有关[1-2]。目前已证实该病与幽门螺杆菌（Helicobacter pylori，Hp）感染密切相关[3]。我国人群中Hp感染率普遍较高，GU患者中的检出率高达60%～90%[4]。Hp通过Hp鞭毛定植，破坏胃黏膜屏障，有研究表示，Hp感染与胃黏膜组织中表皮生长因子（epidermal growth factor，EGF）、前列腺素E2（prostaglandin E2，PGE2）表达改变有关[5]。对于Hp感染既往临床多采用抗Hp三联疗法，但随着多年治疗下Hp耐药性提高，三联疗法治疗Hp根除率逐年下降至65%左右。目前临床普遍推荐使用抗Hp四联疗法，治疗Hp的缓解率和根除率相对较高，耐药性相对较低[6-7]。但在临床应用中也发现部分患者Hp反复感染，重复用药对药物的不良反应增加。中医在治疗GU具有独特见解，调节机体免疫功能，增强胃肠黏膜保护功能来治愈溃疡。本研究应用胃灵颗粒治疗GU，分析其对Hp根除率、EGF、PGE2的作用效果，报道如下。

1 资料与方法

1.1 一般资料

选择2021年1月—2023年7月宜都市人民医院收治的103例GU患者为研究对象。……