钟淑贤　李春　李瑜　方素娟

[摘要]目的：系統评价富血小板血浆治疗雄激素性脱发的有效性，为临床治疗提供参考依据。方法：应用计算机全面检索国内外数据库，纳入符合标准的富血小板血浆治疗雄激素性脱发的随机对照试验，进行文献的筛选、信息提取和质量评价后，进行Meta分析。结果：最终纳入12篇文献，共759例患者。经Meta分析，富血小板血浆治疗雄激素性脱发患者的毛发计数、毛发厚度高于多脱氧核糖核苷酸、或安慰剂、或安慰剂联合治疗，毛发密度、终毛密度高于安慰剂、或安慰剂联合治疗，临床疗效优于米诺地尔、或毛发移植、或安慰剂联合治疗，差异均具有统计学意义（P<0.05）。结论：富血小板血浆能增加毛发数量、毛发密度、毛发厚度和终毛密度，逆转雄激素性脱发患者毛囊逐渐微型化的进程，从而改善患者脱发情况，具有良好的临床疗效。

[关键词]富血小板血浆;雄激素性脱发;脂溢性脱发;Meta分析;毛发计数;毛发密度

[中图分类号]R622    [文献标志码]A    [文章编号]1008-6455（2021）09-0036-05

Meta-analysis of Platelet-rich Plasma in the Treatment of Androgenetic Alopecia

ZHONG Shu-xian1，LI Chun2，LI Yu2，FANG Su-juan3

（1.School of Health，Zhuhai College of Jilin University，Zhuhai 519041，Guangdong，China;2.School of Nursing，Guangzhou University of Traditional Chinese Medicine，Guangzhou 510006，Guangdong，China;3.The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine，Guangzhou 510006，Guangdong，China）

Abstract： Objective  The effectiveness of platelet-rich plasma in the treatment of androgenetic alopecia was systematically evaluated to provide a basis for clinical treatment. Methods  Computers were used to comprehensively search the domestic and foreign databases. Randomized controlled trials of platelet-rich plasma in the treatment of androgenetic alopecia were included. After literature screening， information extraction and quality evaluation， Meta-analysis was performed. Results  Finally， 12 articles were included， with a total of 759 patients. According to Meta-analysis， the hair count and hair thickness of patients with androgenetic alopecia treated with platelet-rich plasma were higher than that treated with polydeoxyribonucleotides， or placebo， or placebo combination therapy. Hair density and terminal hair density were higher than that treated with placebo， or placebo combination therapy. The clinical effects were better than that treated with minoxidil， or hair transplantation， or placebo combination therapy. The differences were statistically significant （P<0.05）. Conclusion  Platelet-rich plasma can increase the number of hairs， hair density， hair thickness and terminal hair density， and reverse the process of miniaturization of hair follicles in patients with androgenetic alopecia. Platelet-rich plasma improves hair loss in patients and has good clinical effects.

Key words： platelet-rich plasma; androgenetic alopecia; seborrheic alopecia; Meta-analysis; hair count; hair density

雄激素性脱发（Androgenetic alopecia，AGA），又称脂溢性脱发，其特征是毛囊的逐渐小型化，毛发生长期缩短，毛发数量减少[1]，临床表现为脱发区皮肤光滑，油脂多、屑多、有明显瘙痒感，额颞区及顶部头发逐渐稀疏甚至全部脱落[2]。雄激素性脱发是临床上最常见的脱发类型，占总脱发人数的84.8%，影响全世界60%～70%的人口[3]，对人的自尊、人际关系和社会地位有很大的影响。富血小板血浆（Platelet-rich plasma，PRP）是自体全血通过离心得到的血小板浓缩物，其包含多种生长因子，对组织的修复、愈合与再生有促进作用[4]。作为一种新型的治疗手段，已广泛应用于皮肤病学领域，在雄激素性脱发的治疗方面具有不可估量的前景。本次研究旨在通过对目前国内外临床应用富血小板血浆治疗雄激素性脱发的随机对照试验结果进行Meta分析，为其在临床应用提供相关循证医学依据，评估富血小板血浆治疗雄激素性脱发的有效性。……