幽门螺杆菌感染对社区2型糖尿病患者的血糖和血脂的影响
2021-10-09王万敏尹相风胡承伟邹凡
王万敏 尹相风 胡承伟 邹凡



摘 要 目的:本研究旨在探讨幽门螺杆菌(Helicobacter pylori,Hp)感染对社区2型糖尿病患者血糖、血脂等指标的影响,为更好的控制2型糖尿病患者血糖水平寻找更多思路。方法:纳入104例2型糖尿病门诊患者,其中男性48名,女性56名,年龄为45~82岁,平均年龄为69.95岁。根据Hp感染情况分为Hp阳性和Hp阴性两组。比较两组患者的年龄、性别、体重指数、血糖、糖化血红蛋白(HbA1c)、血脂。结果:在2型糖尿病患者中检出Hp阳性者64例,检出率为61.5%。Hp阳性组患者的年龄低于阴性组[(67.5±7.29)岁比(69.95.00±4.05)岁,P<0.05]。阳性组平均HbA1c水平和三酰甘油水平高于阴性组[(7.69±1.40)%比(7.12±1.36)%,P<0.05和(1.64±0.65)mmol/L比(1.36±0.55)mmol/L,P<0.05],陰性组患者的HbA1c达标率高于阳性组(57.5%比32.8%,P<0.05)。结论:Hp感染影响2型糖尿病患者的血糖控制,有可能促进糖尿病的发展。
关键词 幽门螺杆菌感染;2型糖尿病;血糖;糖化血红蛋白;血脂
中图分类号:R58 文献标志码:A 文章编号:1006-1533(2021)18-0053-03
Influence of helicobacter pylori infection on blood glucose and blood lipids of type 2 diabetic patients in the community
WANG Wannmin, YIN Xiangfeng, HU Chengwei, ZOU Fan
(General Practice Department of Changzheng Community Health Service Center of Putuo District, Shanghai 200333, China)
ABSTRACT Objective: To explore the influence of helicobacter pylori(HP) infection on blood glucose, blood lipids and other indicators of type 2 diabetic patients in the community to find more ideas for better control of blood glucose levels in patients with type 2 diabetes. Methods: One hundred and four patients with type 2 diabetes were included in the study, there were 48 males and 56 females, and the age ranged from 45 to 82 years old, with an average age of 69.95 years old. According to HP infection, they were divided into the HP positive group and HP negative group. The age, gender, body mass index, blood glucose, glycosylated hemoglobin(HbA1c) and blood lipid of the two groups were compared. Results: In type 2 diabetes patients, 64 cases of HP positive were detected, and the detection rate was 61.5%. The age of the patients in the HP positive group was lower than that in the negative group[(67.5±7.29) years to (69.95.00±4.05) years, P<0.05]. The average HbA1c and triacylglycerol levels in the positive group were higher than those in the negative group[(7.69±1.40)% to (7.12±1.36)%, P<0.05 and (1.64±0.65) mmol/L to (1.36±0.55) mmol/L, P<0.05], the HbA1c compliance rate in the negative group was higher than that in the positive group(57.5% vs. 32.8%, P<0.05). Conclusion: HP infection affects blood glucose control in type 2 diabetic patients, and may promote the development of diabetes.
KEY WORDS helicobacter pylori infection; type 2 diabetes; plasma glucose; glycosylated hemoglobin; blood lipids
目前幽门螺杆菌(Helicobacter pylori,Hp)的全球感染率超过50%[1],我国普通人群中Hp感染的检出率达56.22%[2]。糖尿病是一组以高血糖水平为特征的代谢性疾病,其中2型糖尿病最常见,约占全部糖尿病的90%。在我国成年中,糖尿病患病率估计约10.9%[3]。近年越来越多的研究发现,Hp感染不仅是明确的人类致癌因子[4-5],还与糖尿病、心血管疾病的发生和发展相关[6]。但目前对于社区合并Hp感染的2型糖尿病患者研究较少,对该类患者的管理还不完善,本研究旨在分析Hp感染的2型糖尿病患者的临床特征、血糖水平,为更好的控制2型糖尿病患者血糖水平寻找更多思路。
1 对象和方法
1.1 对象
连续收集2019年1月-2020年12月社区卫生服务中心中符合入选标准的2型糖尿病患者共104名,其中男性48名,女性56名,年龄为45~82岁,平均年龄为69.95岁。所有入组患者均行碳14尿素酶呼气试验(14C-urea breath test,14C-UBT)检测Hp感染。排除……
