蔺莉 闫小宁 李文彬 赵一丁

[摘要]目的：研究尋常痤疮中医药外治组方配伍规律。方法：检索中国期刊全文数据库 （ CNKI） 、万方（WangFang）、维普（Vip）、中国生物医学文献数据库（CBM） ，查找20年间所报道的寻常痤疮外治方药相关文献，利用 Excel 建立方药数据库，对所收集的数据进行方剂和中药名称的规范，应用SPSS22.0、SPSS Modeler进行频数分析、聚类分析、因子分析和关联规则分析。结果：最终符合要求的文献共129篇，所含方剂163首，共有药物179味，以清热药、活血化瘀药、解表药为主;累计频数1 193次，其中32味高频药物频次占总比65%，高频药物可分为4个聚类方，对高频药物进行因子分析得出13个公因子，关联规则分析后以丹参→黄连的支持度最高，达19.53%。 结论：寻常痤疮从血分辨证论治，中医外治原则以清热解表、活血化瘀为主，同时辅以解毒祛风、燥湿止痒。

[关键词]寻常痤疮;中医外治;聚类分析;因子分析;关联规则;用药规律

[中图分类号]R758.73+3   [文献标志码]A   [文章编号]1008-6455（2021）07-0111-04

Study on the Rule of Traditional Chinese Medicine for Acne Vulgaris Based on Literature Mining

LIN Li1，YAN Xiao-ning2 ，LI Wen-bin2，ZHAO Yi-ding2

（1.The First Clinical Medical College of Shaanxi University of Traditional Chinese Medicine，Xianyang 712046，Shaanxi，China; 2.Department of Dermatology，Shaanxi Hospital of Traditional Chinese Medicine，Xi'an 710003，Shaanxi，China）

Abstract： Objective  To study the compatibility of traditional Chinese medicine for acne vulgaris. Methods Search the Chinese Journal Full-text Database （CNKI）， WanFang， Vip， and China Biomedical Literature Database （CBM） to find the literatures related to external treatment of acne vulgaris reported in the 20 years from 2000 to 2019， and use Excel establishes a prescription medicine database， standardizes the prescriptions and names of traditional Chinese medicine on the collected data， and uses SPSS 20.0 and SPSS Modeler to perform frequency analysis， cluster analysis， factor analysis， and association rule analysis. Results  As a result， there were 129 articles that met the requirements， containing 163 prescriptions， with a total of 179 flavors， mainly heat-clearing drugs， promoting blood circulation and removing blood stasis drugs， and anti-surface drugs， the cumulative frequency was 1193 times， of which 32 high-frequency drugs accounted for 65%， high-frequency drugs can be divided into 4 clusters， suitable for factor analysis， and obtained 13 common factors， association rules results show Salvia miltiorrhiza→Huanglian has the highest support， reaching 19.53%. Conclusion The treatment of acne vulgaris is based on the differentiation of blood syndrome. The principle of external treatment of traditional Chinese medicine is to clear away heat and dissolve the surface， promote blood circulation and remove blood stasis， and at the same time supplement with detoxification， expelling wind， dryness and dampness.

Key words：acne vulgaris; external treatment of traditional Chinese medicine; cluster analysis; factor analysis; association rules; medication rules

寻常痤疮 （Acne vulgaris） 是临床常见的慢性炎症性毛囊皮脂腺疾病， 以丘疹、脓疱、囊肿及结节为主要临床表现， 好发于青年男女[1]。西医认为痤疮的发病原因主要与雄激素、皮脂大量分泌及炎性反应等因素有关。中医学又将痤疮称为“面疮”“粉刺”“酒刺”“面皰”“暗疮”等[2]。现代中医认为本病的病因为风热、血热，肺经郁热、血瘀，阴虚，冲任失调等[3]。《外科大成·肺风酒刺》亦云：“肺风由肺经血热郁滞不行而生酒刺也”。认为风热之邪侵入体内，或素体血热，或嗜食辛辣、肥甘，助生内热，日久累及血分，而成血热郁滞，发为痤疮[4]。……