李芳梅 祁希希 韦福巧 蒙菲 颜艳 陈冬琼 冯桥

[摘要]目的：評价中药面膜结合石墨烯电热膜面罩治疗黄褐斑的临床疗效。方法：选取广西国际壮医医院皮肤科门诊黄褐斑患者和志愿者病例100例，将患者随机分为三组。治疗组：34例，石墨烯电热膜面罩结合中药面膜治疗;对照组：34例，中药面膜治疗;观察组：32例，石墨烯电热膜面罩治疗。每周治疗3次，每次30min，4周1个疗程，均治疗3个疗程。使用临床观察表、皮肤镜检测并收集临床照片判断疗效，对资料数据进行统计分析。结果：治疗3个月后，中药面膜结合石墨烯电热膜面罩治疗组有效率91.2%，高于对照组（85.30%）和观察组（37.5%），治疗组与对照组进行比较，无显著性差异（P>0.05），两组与观察组比较，均有统计学意义（P<0.05）;治疗3个月后，三组治疗评分两两进行比较，治疗组与对照组比较，无显著性差异（P>0.05），两组与观察组比较，均具有统计学意义（P<0.05）。治疗后，治疗组皮肤镜评分L值、a值与对照组相比（P<0.05），具有统计学意义;治疗组L值、a值、b值、ITA值与观察组对比（P<0.05），具有统计学意义;对照组与观察组a值相比（P>0.05），差别无统计学意义，L值、b值、ITA值比较（P<0.05），具有统计学意义。结论：中药面膜结合石墨烯电热膜面罩治疗黄褐斑具有较好的临床疗效，较单纯使用中药面膜组显效率更高，可临床推广应用。

[关键词]中药面膜;石墨烯电热面罩;黄褐斑;中药祛斑

[中图分类号]R758.4+2    [文献标志码]A    [文章编号]1008-6455（2021）07-0079-04

Clinical Efficacy of Chinese Medicine Mask Combined with Graphene Electrothermal Mask on Chloasma

LI Fang-mei，QI Xi-xi，WEI Fu-qiao，MENG Fei，YAN Yan，CHEN Dong-qiong，FENG Qiao

（Department of Dermatology，Guangxi International Zhuang Medical Hospital，Nanning 530201，Guangxi，China）

Abstract： Objective  To evaluate the clinical efficacy of Traditional Chinese medicine mask combined with graphene electric heating film mask in the treatment of chloasma. Methods 100 cases of chloasma patients and volunteers from the Dermatology Department of Guangxi International Zhuang Medical Hospital were selected and the patients were randomly divided into treatment groups （34 cases， graphene electric heating film mask combined with traditional Chinese medicine mask treatment）， control group （34 cases， Chinese medicine mask treatment）， observation group （32 cases， graphene electric heating film mask treatment）， 3 times a week， 30 minutes each time， 4 weeks 1 course of treatment， a total of 3 courses of treatment. Use the clinical observation table， dermoscopy and clinical photo collection to determine the efficacy， and perform statistical analysis on the data. Results  After 3 months of treatment， the effective rate of the traditional Chinese medicine mask combined with graphene electrothermal mask group was 91.2 %， which was higher than that of the control group （85.30%） and the observation group （37.5 %）. There was no significant difference between the treatment group and the control group （ P>0.05）. There was statistical significance between the two groups and the observation group （P<0.05）.After treatment， the values of L and a in the treatment group were compared with those in the control group （P<0.05）， with statistical significance.  The L value， a value， b value and ITA value of the treatment group were compared with those of the observation group （P<0.05）， with statistical significance.The control group compared with the observation group， a value （P>0.05）， the difference was not statistically significant， L value， b value， ITA value （P<0.05）， with statistical significance. Conclusion  The combination of Traditional Chinese medicine mask and graphene electric heating mask has a certain clinical effect in treating chloasma，and more effective than simple use of traditional Chinese medicine mask.

Key words： Traditional Chinese medicine mask; graphene electric heating mask; chloasma; traditional chinese medicine freckle; skin disease

黄褐斑是皮肤科常见病、多发病及难治病，临床表现为面部不同程度的边界清楚的淡褐色或深褐色斑片，因为黄褐斑发生于颜面部，颜色比正常皮肤较深，严重损害患者的外在形象，对患者心理和社会交往影响较大[1]。文献资料显示，患有色素代谢异常的人群，如：白癜风、黄褐斑等，比其他损容性疾病更容易出现精神方面的问题。黄褐斑不仅仅是简单的色素代谢异常性皮肤病，也是身心、心理性疾病，可能会长期明显影响患者的人际交往能力、个人形象、自信心、自尊心，甚至导致抑郁症或精神崩溃，需高度重视[2-3]。黄褐……