雷盛钦 钱复 胡水婷 吴琳琳 张素华

【摘要】 目的：探讨舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿的临床疗效。方法：选择本院2017年1月-2019年1月70例变应性鼻炎合并分泌性中耳炎患儿，随机分为治疗组和对照组，每组35例。对照组给予常规治疗，治疗组在对照组基础上给予舌下含服粉尘螨滴剂治疗。比较两组的疗效、不良反应及治疗前和治疗12个月后的VAS评分、听力情况。结果：治疗组总有效率高于对照组，差异有统计学意义（P<0.05）。两组治疗前VAS评分、听力情况比较，差异均无统计学意义（P>0.05）;治疗12个月后，治疗组VAS评分、听力情况均优于对照组，差异均有统计学意义（P<0.05）。两组治疗过程均未出现不良反应。结论：舌下含服粉尘螨滴剂对变应性鼻炎合并分泌性中耳炎患儿安全有效，患儿的临床症状、听力改善显著。

【关键词】 舌下含服 粉尘螨滴剂 变应性鼻炎 分泌性中耳炎

Clinical Efficacy of Sublingual Dermatophagoides Farinae Drops in the Treatment of Allergic Rhinitis Complicated with Secretory Otitis Media/LEI Shengqin， QIAN Fu， HU Shuiting， WU Linlin， ZHANG Suhua. //Medical Innovation of China， 2021， 18（14）： 0-027

[Abstract] Objective： To investigate the clinical efficacy of sublingual Dermatophagoides Farinae Drops in the treatment of allergic rhinitis complicated with secretory otitis media. Method： A total of 70 children with allergic rhinitis complicated with secretory otitis media in our hospital from January 2017 to January 2019 were selected. The children were randomly divided into treatment group and control group， 35 cases in each group. The control group was given routine treatment， and the treatment group was given sublingual Dermatophagoides Farinae Drops on the basis of the control group. The efficacy， adverse reactions were compared between the two groups， and the VAS scores and hearing before and 12 months after treatment were compared between the two groups. Result： The total effective rate of the treatment group was higher than that of the control group， the difference was statistically significant （P<0.05）. There were no significant differences in VAS scores and hearing between the two groups before treatment （P>0.05）; 12 months after treatment， VAS scores and hearing of the treatment group were better than those of the control group， with statistical significance （P<0.05）. There were no adverse reactions in the two groups. Conclusion： Sublingual Dermatophagoides Farinae Drops is safe and effective for children with allergic rhinitis complicated with secretory otitis media， and the clinical symptoms and hearing of the children are improved significantly.

[Key words] Sublingual administration Dermatophagoides Farinae Drops Allergic rhinitis Secretory otitis media

First-authors address： Maternal and Child Health Hospital of Jiujiang City， Jiujiang 332000， China

doi：10.3969/j.issn.1674-4985.2021.14.006

變态反应是分泌性中耳炎的一个致病因素，变应性鼻炎与分泌性中耳炎有着密切的联系。分泌性中耳炎主要表现为听力下降与中耳积液，多见于儿童，常与儿童鼻窦炎、变应性鼻炎、腺样体肥大等并发，变应性鼻炎虽无生命危险，但与支气管哮喘、鼻窦炎、结膜炎等变态反应性疾病密切相关，影响了患者的生活质量，已成为全球性的健康问题。变应原特异性免疫治疗是唯一可能改变过敏性疾病自然进程的治疗措施，其中舌下特异性免疫是一种安全、有效、方便的新型治疗方法，其对分泌性中耳炎合并变应性鼻炎作用的研究还鲜有报道。本研究旨在通过评估舌下含服粉尘螨滴剂对分泌性中耳炎合并变应性鼻炎患者的疗效和安全性，为临床上使用舌下特异性免疫治疗治疗分泌性中耳炎合并变应性鼻炎提供必要的依据。……