周领航 谭劲

【摘要】 目的：分析高壓氧联合醋酸曲安奈德注射液局部封闭治疗口腔黏膜下纤维性变（OSF）的效果及对E-钙黏蛋白（E-cadherin）、转化生长因子-β1（TGF-β1）表达的影响。方法：选取2019年1月-2020年1月本院收治的80例OSF患者，以信封法随机分为试验组及对照组，每组40例。对照组采用醋酸曲安奈德注射液局部封闭治疗，试验组在对照组基础上加用高压氧进行治疗。比较两组患者治疗前后口腔黏膜病损面积、张口度、E-cadherin、TGF-β1水平及临床治疗效果。结果：治疗后，两组口腔黏膜病损面积、张口度、E-cadherin及TGF-β1水平均优于治疗前（P<0.05），且试验组口腔黏膜病损面积小于对照组，TGF-β1水平低于对照组，E-cadherin水平及张口度均高于对照组（P<0.05）。试验组总有效率高于对照组（P<0.05）。结论：应用高压氧联合醋酸曲安奈德注射液局部封闭治疗OSF患者，可改善患者临床症状，临床效果明确，具有较高临床推广应用价值。

【关键词】 高压氧 醋酸曲安奈德注射液 口腔黏膜下纤维性变

Efficacy of Hyperbaric Oxygen Combined with Triainclnolone Acetonide Acetate Injection in the Treatment of Oral Submucosal Fibrosis and Its Effect on the Expression of E-cadherin and Transforming Growth Factor-β1/ZHOU Linghang， TAN Jin. //Medical Innovation of China， 2021， 18（14）： 0-043

[Abstract] Objective： To analyze the effect of hyperbaric oxygen combined with Triainclnolone Acetonide Acetate Injection in the treatment of oral submucosal fibrosis （OSF） and its effect on the expression of E-cadherin and transforming growth factor-β1 （TGF-β1）. Method： A total of 80 patients with OSF admitted to the hospital from January 2019 to January 2020 were selected as the research subjects， they were randomly divide into the experimental group and the control group by the envelope method， 40 cases in each group. The control group was treated with Triainclnolone Acetonide Acetate Injection local blocking therapy， and the experimental group was treated with hyperbaric oxygen on the basis of the control group. Oral mucosal lesion area， mouth opening degree， levels of E-cadherin， TGF-β1 were compared between two groups before and after treatment， and clinical treatment effect were compared between two groups. Result： After treatment， the oral mucosal lesion area， mouth opening degree， E-cadherin and TGF-β1 levels in both groups were better than those before treatment （P<0.05）， and the oral mucosal lesion area， TGF-β1 level in experimental group were lower than those in control group， E-cadherin level and mouth opening degree in experimental group were higher than those in control group （P<0.05）. The total effective rate of the experimental group was higher than that of the control group （P<0.05）. Conclusion： Local blocking therapy of hyperbaric oxygen combined with Triamcinolone Acetonide Acetate Injection in the treatment of patients with OSF can improve the clinical symptoms of patients， and the clinical treatment effect is clear， which has high clinical promotion and application value.

[Key words] Hyperbaric oxygen Triainclnolone Acetonide Acetate Injection Oral submucosal fibrosis

First-authors address： The First Hospital of Hunan University of Chinese Medicine， Changsha 410000， China

doi：10.3969/j.issn.1674-4985.2021.14.010

口腔黏膜下纤维性变（OSF）是一种慢性渐进性且有癌变倾向的口腔黏膜疾病，临床主要表现为口腔内灼烧感、口干、口腔黏膜逐渐灰白、僵硬、进行性张口受限、吞咽困难等[1-2]。目前临床治疗该病主要手段为局部注射糖皮质激素，但单纯使用糖皮质激素虽可预防局部炎性反应，但其无法逆转纤维化，且多伴有副作用[3]。醋酸曲安奈德属于糖皮质激素，具有抗炎、抗感染、抑制纤维细胞增殖等作用，但长期使用会增加机体代谢紊乱风险[4-5]。研究显示，高压氧疗具有杀菌、消炎、抗感染、提高血氧含量等作用，可用于口腔疾病[6-7]。两者均可应用于口腔疾病，但关于两者联合应用治疗OSF患者的相关研究较少。故本研究采用高压氧联合醋酸曲安奈德治疗OSF患者，并观察分析其临床治疗效果，旨在为OSF患者提供临床治疗方案的参考，现报道如下。……