朱立强

【摘要】 目的：比较逍遥汤和黄芪建中汤对杀灭幽门螺旋杆菌（Hp）的疗效。方法：选取2017年8月-2019年9月本院收治的156例Hp阳性胃溃疡患者，按照随机数字表法将其分成逍遥汤治疗组、黄芪建中汤治疗组和常规组，每组52例。常规组采用常规西药治疗，逍遥汤治疗组在常规组基础上采用逍遥汤治疗，黄芪建中汤治疗组在常规组的基础上采用黄芪建中汤治疗。比较三组Hp根除率、不良反应发生情况及溃疡复发情况。结果：黄芪建中汤治疗组Hp根除率高于逍遥汤治疗组和常规组（P<0.05）;黄芪建中汤治疗组和逍遥汤治疗组的不良反应发生率及溃疡复发率均低于常規组（P<0.05）。结论：在常规西药治疗基础上加用逍遥汤和黄芪建中汤均具有显著的杀灭Hp的作用，且不良反应发生率及溃疡复发率低，其中联合黄芪建中汤Hp根除率更高，具有临床应用价值。

【关键词】 逍遥汤 黄芪建中汤 幽门螺杆菌 胃溃疡

[Abstract] Objective： To compare the efficacy of Xiaoyao Decoction and Huangqi Jianzhong Decoction in killing Helicobacter pylori （Hp）. Method： A total of 156 patients with Hp positive gastric ulcer treated in our hospital from August 2017 to September 2019 were selected. They were divided into Xiaoyao Decoction treatment group， Huangqi Jianzhong Decoction treatment group and routine group according to random number table method， with 52 cases in each group. The routine group was treated with conventional western medicine， the Xiaoyao Decoction treatment group was treated with Xiaoyao Decoction on the basis of the routine group， and the Huangqi Jianzhong Decoction treatment group was treated with Huangqi Jianzhong Decoction on the basis of the routine group. The Hp eradication rate， the incidence of adverse reactions and the recurrence of ulcer were compared among the three groups. Result： The Hp eradication rate in the Huangqi Jianzhong Decoction treatment group was higher than that in the Xiaoyao Decoction treatment group and the routine group （P<0.05）. The adverse reaction rate and recurrence rate of ulcer in the Huangqi Jianzhong Decoction treatment group and the Xiaoyao Decoction treatment group were lower than those in the routine group （P<0.05）. Conclusion： On the basis of conventional western medicine treatment， Xiaoyao Decoction and Huangqi Jianzhong Decoction have significant effect on killing Hp， and the incidence of adverse reaction and recurrence rate of ulcer are low. Amang them， the Hp eradication rate of combined Huangqi Jianzhong Decoction is higher， which had clinical application value.

[Key words] Xiaoyao Decoction Huangqi Jianzhong Decoction Helicobacter pylori Gastric ulcer

First-authors address： The First Peoples Hospital of Ningyang， Ningyang 271400， China

doi：10.3969/j.issn.1674-4985.2021.08.022

幽门螺杆菌（helicobacter pylori，Hp）是一种革兰阴性杆菌，常寄生于人类胃黏膜，是唯一能在胃内生存的细菌[1-2]。有资料表明，全世界大约有一半人群感染Hp，我国Hp感染率高达60%[3]。据调查，Hp感染与胃十二指肠溃疡、慢性胃炎、胃癌等密切相关，其中Hp感染所致胃溃疡越来越常见。研究表明，Hp感染诱发胃溃疡的作用机制是Hp可以使胃黏膜产生酶和毒素，从而诱发炎症，破坏胃黏膜组织，导致溃疡的发生[4]。因此，根除Hp是治疗Hp阳性胃溃疡患者的关键[5-6]。目前临床上常用的药物以西药为主，主要有奥美拉唑、甲硝唑等，但其副作用大，部分患者难以接受。近年来，联合中药治疗Hp阳性胃溃疡的效果越来越被大众所接受，目前常用的中药有逍遥汤和黄芪建中汤。本研究选取2017年8月-2019年9月本院收治的156例Hp阳性胃溃疡患者，分为逍遥汤治疗组、黄芪建中汤治疗组和常规组，旨在分析比较在西药基础上联合逍遥汤和黄芪建中汤根除Hp的疗效，现报道如下。……