袁玉

【摘要】 目的：研究左卡尼汀对心功能异常的重症手足口病患儿的临床效果及对心肌酶的影响。方法：选取2017年1月-2019年11月就诊于本院的80例心功能异常的重症手足口病患儿为研究对象，根据治疗方法的不同将其分为对照组和观察组，各40例。对照组进行常规治疗，观察组则在对照组基础上加用左卡尼汀。比较两组的总有效率、治疗前后的心肌损伤指标、心肌酶指标及心功能指标。结果：观察组治疗3、7 d的总有效率均高于对照组，差异均有统计学意义（P<0.05）。治疗后，两组的心肌损伤指标、心肌酶指标及心功能指标均改善，且观察组各项指标均优于对照组，差异均有统计学意义（P<0.05）。结论：左卡尼汀在心功能异常的重症手足口病患儿中的临床效果较好，且对心肌酶的改善较为显著，在本类患儿中的应用价值较高。

【关键词】 左卡尼汀 心功能异常 重症手足口病 心肌酶

Study on the Clinical Effect of Levocarnitine in the Children with Severe Hand-foot-and-mouth Disease Complicated with Cardiac Dysfunction and Influence for Myocardial Enzyme/YUAN Yu. //Medical Innovation of China， 2021， 18（01）： 0-073

[Abstract] Objective： To study the clinical effect of Levocarnitine in the children with severe hand-foot-and-mouth disease complicated with cardiac dysfunction and influence for myocardial enzyme. Method： A total of 80 cases of severe hand-foot-mouth disease with cardiac dysfunction admitted to our hospital from January 2017 to November 2019 were selected as the research objects， they were divided into control group and observation group， 40 cases in each group， according to different treatment methods. The control group were treated with routine treatment， the observation group were treated with Levocarnitine based on the treatment of control group. Then the total clinical effective rates，myocardial injury indexes，myocardial enzyme indexes and cardiac function indexes before and after the treatment of two groups were compared. Result： The total effective rate of the observation group were higher than those of the control group for 3 and 7 days after treatment， the difference were statistically significant （P<0.05）. After treatment， myocardial injury indexes， myocardial enzyme indexes and cardiac function indexes of the two groups were improved， all indexes of the observation group were superior to those of the control group， with statistically significant differences （P<0.05）. Conclusion： The clinical effect of Levocarnitine in the children with severe hand-foot-and-mouth disease complicated with cardiac dysfunction is better， its effect for myocardial enzyme has improve significantly，so its application value is higher in these children.

[Key words] Levocarnitine Cardiac dysfunction Severe hand-foot-and-mouth disease Myocardial enzyme

First-authors address： Jiamusi Maternal and Child Health Hospital， Jiamusi 154000， China

doi：10.3969/j.issn.1674-4985.2021.01.018

重癥手足口病可对患儿的多系统器官造成不良影响，其中循环系统是受累较多的一类情况，患儿的心肌受到影响，表现出心率异常，心肌受损等情况[1-2]，心功能异常也是本类患儿亟待改善的方面。对于本类患儿的治疗过程中，心肌酶是重要的监测指标，同时也是疗效评估的重要方面。近年来临床中以左卡尼汀用于本类患儿的研究可见[3-4]，但是其综合的效果研究仍有所不足。因此本研究就左卡尼汀对心功能异常的重症手足口病患儿的临床效果及对心肌酶的影响进行探究，现报道如下。

1 资料与方法

1.1 一般资料 选取2017年1月-2019年11月于本院就诊的80例心功能异常的重症手足口病患儿为研究对象。納入标准：14岁以下;重症手足口病;心功能异常。排除标准：心脏疾病史;慢性疾病;合并其他传染性疾病;心电图正常。根据治疗方法不同将其分为对照组和观察组，各40例。……