程武 张美玲 张巧梅 李晓东

【摘要】 目的：探究與分析肝癌患者组织CCT6A表达情况及与疾病分期的关系。方法：选取2019年1月-2021年3月福建中医药大学附属第三人民医院90例肝癌患者为观察组，同期90例肝脏良性病变患者为对照组。比较两组的组织CCT6A阳性表达率，比较观察组中不同年龄、性别、病灶直径、血清甲胎蛋白（AFP）水平及疾病分期患者的CCT6A阳性表达率，采用Spearman秩相关分析组织CCT6A表达情况及与肝癌疾病分期的关系。结果：观察组患者组织CCT6A阳性表达率显著高于对照组，差异有统计学意义（P<0.05）;观察组中不同年龄、性别、病灶直径及血清AFP水平患者的组织CCT6A阳性表达率比较，差异均无统计学意义（P>0.05）;观察组中疾病分期较高患者的组织CCT6A阳性表达率显著高于疾病分期较低患者，差异有统计学意义（P<0.05）;Spearman秩相关分析显示，组织CCT6A表达情况与肝癌疾病分期呈正相关（rs=0.796，P<0.05）。结论：肝癌患者的组织CCT6A呈现高表达状态，且与肝癌的疾病分期有密切的关系，因此在肝癌患者中的检测价值较高。

【关键词】 肝癌 组织 CCT6A表达 疾病分期 关系

Investigation on the Expression Situation of Tissue CCT6A of Patients with Liver Cancer and Relationship with Disease Stage/CHENG Wu， ZHANG Meiling， ZHANG Qiaomei， LI Xiaodong. //Medical Innovation of China， 2021， 18（34）： -157

[Abstract] Objective： To investigate and analyze the expression situation of tissue CCT6A of patients with liver cancer and relationship with disease stage. Method： A total of 90 patients with liver cancer from January 2019 to March 2021 in the Third People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine were chosen as the observation group， 90 patients with benign liver lesions at the same time were chosen as the control group. Then the tissue CCT6A positive rates of two groups were compared， and the tissue CCT6A positive rates of observation group with different ages， gender， lesion diameter， serum alpha-fetoprotein （AFP） levels and disease stages were compared， then the tissue CCT6A expression situation and disease stages of liver cancer were analyzed with Spearman rank correlation analysis. Result： The tissue CCT6A positive rate of observation group was significantly higher than that of control group， there was statistically significant difference （P<0.05）; the tissue CCT6A positive rates of observation group with different ages， gender， lesion diameter and serum AFP levels were compared， there were no statistically significant differences （P>0.05）. In the observation group， the positive expression rate of CCT6A in patients with higher disease stage was significantly higher than that in patients with lower disease stage， there were statistically significant differences （P<0.05）; the Spearman rank correlation analysis showed the tissue CCT6A was positively correlated with disease stage of liver cancer （rs=0.796， P<0.05）. Conclusion： The tissue CCT6A of patients with liver cancer show higher expression state，and it is closely related to disease stage，so its detection value in the patients with liver cancer is higher.

[Key words] Liver cancer Tissue CCT6A expression Disease stage Relationship

First-author’s address： The Third People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine， Fuzhou 350108， China

doi：10.3969/j.issn.1674-4985.2021.34.037

肝癌的临床发病率较高，具有较高的死亡率，而对于本病的早期有效诊治是改善预后的必要前提。临床中与肝癌相关的研究中，关于病灶组织中各类指标的表达研究是重点，对于肝癌相关指标的研究与掌握是临床研究占比较高的方面[1-2]，也是研究结果差异较大的方面。近年来关于CCT6A在各类恶性肿瘤患者中的表达研究不断增多，其中关于本类指标在肝癌患者中的表达研究也可见[3-5]，但是其与疾病分期的关系有待进一步研究。……