严金武　陈远洋 郑俊斌 　谢凤 　张秀文 　滕菁

【摘要】 目的：探究及分析糖尿病肾病患者尿路感染发生情况及危险因素。方法：选取2015年3月-2020年11月厦门市中医院260例糖尿病肾病患者为研究对象，统计其尿路感染发生率，同時比较不同性别、年龄、病程、糖化血红蛋白水平、白蛋白水平、并发症、合并基础疾病情况、导尿管留置情况、糖尿病肾病分期、抗生素应用情况及既往尿路感染史患者的尿路感染发生率，采用多因素logistic回归分析糖尿病肾病患者尿路感染发生的危险因素。结果：260例糖尿病肾病患者中发生尿路感染68例，发生率为26.15%。不同糖尿病肾病分期患者的尿路感染发生率比较，差异无统计学意义（P>0.05）。女性、年龄>60岁、病程>10年、糖化血红蛋白>7.5%、白蛋白<30 g/L、合并其他并发症、合并其他基础疾病、留置导尿管、应用抗生素及既往尿路感染史患者的尿路感染发生率显著高于男性、≤60岁、病程≤10年、糖化血红蛋白≤7.5%、白蛋白≥30 g/L、无其他并发症、无其他基础疾病、未留置导尿管、未应用抗生素及既往无尿路感染史的患者，差异均有统计学意义（P<0.05）。多因素logistic回归分析显示，女性、年龄>60岁、病程>10年、糖化血红蛋白>7.5%、白蛋白<30 g/L、合并其他并发症、合并其他基础疾病、留置导尿管、应用抗生素及既往尿路感染史是糖尿病肾病患者尿路感染发生的危险因素（P<0.05）。结论：糖尿病肾病患者尿路感染发生率较高，且危险因素较多，应加强对上述因素的监测与干预。

【关键词】 糖尿病肾病 尿路感染 危险因素

Analysis and Study on the Incidence of Urinary Tract Infection of Patients with Diabetic Nephropathy and Its Risk Factors/YAN Jinwu， CHEN Yuanyang， ZHENG Junbin， XIE Feng， ZHANG Xiuwen， TENG Jing. //Medical Innovation of China， 2021， 18（34）： -134

[Abstract] Objective： To investigate and analyze the incidence of urinary tract infection of patients with diabetic nephropathy and its risk factors. Method： A total of 260 patients with diabetic nephropathy in Xiamen Traditional Chinese Medicine Hospital from March 2015 to November 2020 were chosen as the study object， and the urinary tract infection rate of all the patients was analyzed，and the urinary tract infection rates of patients with different gender， ages， course of disease， glycosylated hemoglobin， albumin level， complications， basic diseases， catheter indwelling， diabetic nephropathy stages， antibiotic application and urinary tract infection history were compared， then the risk factors of urinary tract infection of patients with diabetic nephropathy were analyzed with multivariate logistic regression analysis. Result： A total of 68 cases of 260 patients with diabetic nephropathy were with urinary tract infection， the rate was 26.15%. The urinary tract infection rates of patients with different diabetic nephropathy stages were compared， there was no statistically significant difference （P>0.05）. While the urinary tract infection rates of patients with female， >60 years old， course of disease >10 years， glycosylated hemoglobin>7.5%， albumin level<30 g/L， other complications， other basic disease， catheter indwelling， antibiotic application and urinary tract infection history were significantly higher than those of male， ≤60 years old，course of disease ≤10 years， glycosylated hemoglobin ≤7.5%， albumin level ≥30 g/L， without other complications， without other basic disease，without catheter indwelling， without antibiotic application and no urinary tract infection history， there were statistically significant differences （P<0.05）. The multivariate logistic regression analysis showed the female， >60 years old， course of disease >10 years， glycosylated hemoglobin >7.5%， albumin level <30 g/L， other complications， other basic disease， catheter indwelling， antibiotic application and urinary tract infection history were the risk factors of urinary tract infection of patients with diabetic nephropathy （P<0.05）. Conclusion： The incidence of urinary tract infection of patients with diabetic nephropathy is high， and its risk factors are more， so those factors should be paid to more monitoring and intervention.

[Key words] Diabetic nephropathy Urinary tract infection Risk factors

First-author’s address： Xiamen Traditional Chinese Medicine Hospital， Xiamen 361000， China

doi：10.3969/j.issn.1674-4985.2021.34.031

糖尿病肾病作为糖尿病的严重并发症，其对患者的危害显著，该疾病患者更易于发生各类感染，其中尿路感染是常见感染类型之一。……