贺应林 张磊昌

【摘要】 目的：探究清热解毒、益气止血方治疗急性放射性肠炎的效果及对患者血清炎症因子的影响，为临床提供理论参考。方法：选取2020年1月-2021年6月本院收治的200例急性放射性肠炎患者作为研究对象，经随机数字表法分为对照组和观察组，各100例。对照组采用常规西医药物保留灌肠治疗，观察组采用清热解毒、益气止血方保留灌肠治疗，比较两组临床疗效、中医症候积分、血清炎症因子和不良反应发生情况。结果：观察组总有效率为93.00%，高于对照组的84.00%，差异有统计学意义（P<0.05）。治疗前，两组腹痛、排便困难、里急后重积分，CRP、IL-6、TNF-α水平比较，差异均无统计学意义（P>0.05）;治疗后，两组腹痛、排便困难、里急后重积分，CRP、IL-6、TNF-α水平均低于治療前，且观察组均低于对照组，差异均有统计学意义（P<0.05）。观察组不良反应发生率为4.00%，低于对照组的15.00%，差异有统计学意义（P<0.05）。结论：清热解毒、益气止血方治疗急性放射性肠炎效果确切，可促进患者临床症状和血清炎症因子水平的改善，安全性较高，值得推广及应用。

【关键词】 急性放射性肠炎 清热解毒 益气止血 炎症因子

Effect of Qingre Jiedu， Yiqi Zhixue Recipe on Acute Radiation Enteritis and Its Effect on Serum Inflammatory Factors/HE Yinglin， ZHANG Leichang. //Medical Innovation of China， 2021， 18（34）： -123

[Abstract] Objective： To explore the efficacy of Qingre Jiedu， Yiqi Zhixue Recipe in the treatment of acute radiation enteritis and its effect on serum inflammatory factors， so as to provide theoretical reference for clinical practice. Method： A total of 200 patients with acute radiation enteritis treated in our hospital from January 2020 to June 2021 were randomly divided into control group and observation group， with 100 cases in each group. The control group was treated with conventional western medicine retention enema， and the observation group was treated with Qingre Jiedu， Yiqi Zhixue Recipe retention enema. The clinical efficacy， TCM syndrome score， serum inflammatory factors and adverse reactions were compared between the two groups. Result： The total effective rate was 93.00% in the observation group， which was higher than 84.00% in the control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences between the two groups in abdominal pain， difficulty in defecation， tenesmus scores， CRP， IL-6 and TNF-α （P>0.05）; after treatment， abdominal pain， difficulty in defecation， tenesmus scores， CRP， IL-6 and TNF-α in the two groups were lower than those before treatment， and those in the observation group were lower than those in the control group， the differences were statistically significant （P<0.05）. The adverse reaction rate of the observation group was 4.00%， which was significantly lower than 15.00% of the control group， the difference was statistically significant （P<0.05）. Conclusion： Qingre Jiedu， Yiqi Zhixue Recipe is effective in the treatment of acute radiation enteritis. It can promote the improvement of clinical symptoms and serum inflammatory factor level. It has high safety and is worthy of popularization and application.

[Key words] Acute radiation enteritis Qingre Jiedu Yiqi Zhixue Inflammatory factors

First-author’s address： Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine， Nanchang 330006， China

doi：10.3969/j.issn.1674-4985.2021.34.028

急性放射性肠炎是指因直肠或骨盆内脏器经放疗后引起的肠炎，在临床上较为常见，具有较高的发病率，一般为5%～17%，肠黏膜可发生溃疡、糜烂、出血等，严重影响患者的健康，降低生存质量[1]。近年来，急性放射性肠炎的发病率逐年上升，且呈现一定的年轻化趋势[2]。西医药物保留灌肠治疗是急性放射性肠炎的常见方式，尽管可以取得一定的效果，但治疗后会引发较多的不良反应[3]。……