逯越

摘 要 目的：研究复方甘草酸苷与美沙拉嗪联合治疗溃疡性结肠炎的临床效果。方法：选取溃疡性结肠炎患者72例，随机分为观察组和对照组各36例。对照组使用美沙拉嗪进行治疗，观察组在此基础上给予复方甘草酸苷与美沙拉嗪治疗。对比两组治疗后的血清炎症因子水平、溃疡性结肠炎复发率、并发症发生率和不良反应发生情况。结果：治疗后，观察组血清hs-CRP、IL-6、IL-7水平，以及复发率、并发症和不良反应发生率均明显低于对照组，且治疗总有效率显著高于对照组（88.89% vs 69.44%）。结论：采用复方甘草酸苷与美沙拉嗪联合治疗溃疡性结肠炎的临床疗效显著、复发率低、安全性较高。

关键词 复方甘草酸苷 美沙拉嗪 溃疡性结肠炎

中图分类号：R975.5； R574.6 文献标志码：B 文章编号：1006-1533（2021）03-0021-03

Effect of compound glycyrrhizin combined with mesalazine on ulcerative colitis

LU Yue*

（Department of Digestive Medicine， the Seventh Peoples Hospital of Zhengzhou， Zhengzhou 450000， China）

ABSTRACT Objective： To study the clinical effect of compound glycyrrhizin combined with mesalazine on ulcerative colitis. Methods： Seventy-two patients with ulcerative colitis were randomly divided into an observation group and a control group. The control group was treated with mesalazine， and the observation group was treated with compound glycyrrhizin and mesalazine. Serum levels of inflammatory factors， recurrence rate of ulcerative colitis， complication rate and adverse reactions were compared between the two groups. Results： After treatment， the levels of serum hs-CRP， IL-6， IL-7， recurrence rate， complications and adverse reactions were significantly lower and the overall response rate was significantly higher （88.89% vs 69.44%） in the observation group than the control group. Conclusion： Compound glycyrrhizin combined with mesalazine is effective and safe in the treatment of ulcerative colitis.

KEY WORDS compound glycyrrhizin； mesalazine； ulcerative colitis

溃疡性结肠炎是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病，多位于乙状结肠和直肠，也可延伸至降结肠，甚至整个结肠。该病病变常局限于大肠黏膜及黏膜下层，病程漫长，常反复发作，可见于任何年龄，其主要的临床表现为血性腹泻、腹痛、血便、呕吐、体重减轻、里急后重等症状，严重时会引发结肠癌[1]。轻症可以药物治疗，重症者需手术治疗。目前临床上西医多采用药物对症治疗，但是因为复发率高、不良反应大，所以临床疗效欠佳。为研究采用复方甘草酸苷联合美沙拉嗪治疗溃疡性结肠炎的疗效和可行性，特选取我院就诊的72例轻中度溃疡性结肠炎患者作为研究对象，采用复方甘草酸苷联合美沙拉嗪进行治疗，临床效果显著。……