陈勇军

【摘要】 目的 探討低剂量罗红霉素治疗慢性鼻窦炎并发鼻息肉的临床效果。方法 54例慢性鼻窦炎并发鼻息肉患者， 采用随机数字表法分为对照组和观察组， 各27例。对照组给予传统鼻喷激素治疗， 观察组给予低剂量罗红霉素治疗。比较两组患者的治疗后对患者效果进行评估， 比较临床症状改善情况与满意度。结果 治疗前， 两组鼻塞、头痛与嗅觉下降评分比较， 差异无统计学意义（P>0.05）;治疗后， 两组鼻塞、头痛与嗅觉下降评分均高于治疗前， 且观察组鼻塞评分（64.98±5.79）分、头痛评分（64.56±8.67）分与嗅觉下降评分（65.64±8.67）分均明显高于对照组的（46.15±6.42）、（38.52±8.66）、（48.52±8.66）评分， 差异有统计学意义（P<0.05）。观察组治疗满意度92.59%明显高于对照组的55.56%， 差异具有统计学意义（P<0.05）。结论 将低剂量罗红霉素药物应用于慢性鼻窦炎并发鼻息肉的治疗中能提高患者治疗效果， 减少不良影响， 治疗满意度较高， 值得推广应用。

【关键词】 罗红霉素;慢性鼻窦炎并发鼻息肉;治疗效果;满意度

DOI：10.14163/j.cnki.11-5547/r.2020.22.053

Clinical study of low-dose roxithromycin in the treatment of chronic sinusitis nasal complicated by polyps   CHEN Yong-jun. Taishan Hospital of Traditional Chinese Medicine， Jiangmen 529200， China

【Abstract】 Objective   To discuss the clinical effect of low-dose roxithromycin in the treatment of chronic sinusitis nasal complicated by polyps. Methods   A total of 54 patients with chronic sinusitis nasal complicated by polyps were divided into control group and observation group according to random numerical table， with27 cases in each group. The control group was treated by traditional nasal spray hormone， and the observation group was treated by low-dose roxithromycin. The improvement of clinical symptoms and satisfaction degree were compared between the two groups. Results   Before treatment， there was no statistically significant difference in nasal congestion， headache and olfactory decline score between the two groups （P>0.05）. After treatment， nasal congestion， headache and olfactory decline score of the two groups were higher than those before treatment. The nasal congestion， headache and olfactory decline score of the observation group were （64.98±5.79）， （64.56±8.67） and （65.64±8.67） points， which were obviously higher than those of the control group （46.15±6.42）， （38.52±8.66） and （48.52±8.66） points， and the difference was statistically significant （P<0.05）. The satisfaction with treatment 92.59% of the observation group was obviously higher than that of the control group 55.56%， and the difference was statistically significant （P<0.05）. Conclusion   Application of low-dose roxithromycin in chronic sinusitis nasal complicated by polyps can improve therapeutic effect and reduce adverse effects of patients， and make patients satisfied， so it is worthy promotion and application.

【Key words】 Roxithromycin; Chronic sinusitis nasal complicated by polyps; Therapeutic effect; Satisfactions degree

慢性鼻窦炎在临床上常表现为鼻塞、鼻痛、浓涕等症状， 严重时还有可能导致患者出现并发症， 感染加重甚至死亡， 而慢性鼻窦炎并发鼻息肉作为严重的疾病之一， 积极治疗对患者来说尤为重要[1]。而罗红霉素作为大环内酯抗生素类的新一代西医药物， 具有较强的抗菌作用， 在治疗慢性鼻窦炎并发鼻息肉中得到广泛应用[2]。因此， 本文选取54例慢性鼻窦炎并发鼻息肉患者， 探讨低剂量罗红霉素治疗慢性鼻窦炎并发鼻息肉的临床效果， 报告如下。

1 资料与方法

1. 1 一般资料 选择2018年在本院接受治疗的54例慢性鼻窦炎并发鼻息肉患者作为研究对象， 采用随机数字表法分为对照组和观察组， 各27例。对照组男15例， 女12例;年龄20～48岁， 平均年龄（34.82±8.83）岁。观察组男14例， 女13例;年龄21～50岁， 平均年龄（35.72±9.73）岁。两组……