魏蓉

【摘要】 目的：探讨疏肝补肾汤对多囊卵巢综合征（PCOS）不孕症患者血清性激素及妊娠率的影响。方法：选取2017年3月-2019年6月就诊于笔者所在医院的84例PCOS不孕症患者，按随机数字表法分为两组，各42例。B组口服来曲唑片治疗，A组在此基础上加用疏肝补肾汤治疗。比较两组临床疗效、性激素、排卵率及妊娠率。结果：A组治疗总有效率、雌二醇（E2）均高于B组，睾酮（T）、促黄体激素（LH）均低于B组，差异均有统计学意义（P<0.05）;A组排卵率、妊娠率均高于B组，差异均有统计学意义（P<0.05）。结论：疏肝补肾汤可有效改善PCOS不孕症患者性激素水平，提高排卵率、妊娠率，值得临床推广。

【关键词】 不孕症 疏肝补肾汤 多囊卵巢综合征 性激素 妊娠率

doi：10.14033/j.cnki.cfmr.2020.19.049 文献标识码 B 文章编号 1674-6805（2020）19-0-03

Effect of Shugan Bushen Decoction on Serum Sex Hormones and Pregnancy Rate in Patients with Polycystic Ovary Syndrome Infertility/WEI Rong. //Chinese and Foreign Medical Research， 2020， 18（19）： -123

[Abstract] Objective： To investigate the effect of Shugan Bushen Decoction on serum sex hormones and pregnancy rate in patients with polycystic ovary syndrome （PCOS） infertility. Method： A total of 84 patients with PCOS infertility who were treated in our hospital from March 2017 to June 2019 were selected and divided into two groups according to the random number table method. Group B was treated with Letrozole Tablets， and group A was treated with Shugan Bushen Decoction. The clinical efficacy， sex hormones， ovulation rate and pregnancy rate were compared between the two groups. Result： The total effective rate of treatment， estradiol （E2） in group A were higher than those in group B， and testosterone （T） and luteinizing hormone （LH） were lower than those in group B， the differences were statistically significant （P<0.05）. The ovulation rate and pregnancy rate in group A were higher than those in group B， the differences were statistically significant （P<0.05）. Conclusion： Shugan Bushen Decoction can effectively improve the level of sex hormones， increase ovulation rate and pregnancy rate in patients with PCOS infertility， which is worthy of clinical promotion.

[Key words] Infertility Shugan Bushen Decoction Polycystic ovary syndrome Sex hormones Pregnancy rate

First-authors address： The Second Affiliated Hospital of Fujian Medical University， Quanzhou 362000， China

多囊卵巢綜合征（PCOS）是一种表现为卵巢多囊改变、月经不调、雄激素升高、功能性子宫出血、闭经等内分泌紊乱性疾病，同时其诱发的排卵障碍是导致不孕症的重要因素之一，需及时加以治疗[1-3]。西医对于PCOS不孕症多使用来曲唑等促排卵药物治疗，虽有一定效果，但长期使用易出现副作用，且停药后易复发，难以达到理想治疗效果[4-5]。中医认为PCOS不孕症属于“闭经”“不孕”“月经后期”等范畴，病因病机复杂，与肾、肝、冲任密切相关，经中医理论中整体、辩证医治观念治疗，疗效显著。本研究旨在分析疏肝补肾汤治疗PCOS不孕症患者临床效果，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年3月-2019年6月就诊于笔者所在医院的84例PCOS不孕症患者。诊断标准：西医符合《妇产科学》中PCOS不孕症相关诊断标准[6];中医符合《中医妇科学》中肾虚血瘀型PCOS不孕症诊断标准：主证不孕、闭经、腰起酸痛、月经量少、有血块、色暗;次证神疲乏力、性欲减退、夜尿频多;舌淡紫、脉细涩[7]。……